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RNA, Double-Stranded - Immunology
Research News and Information
Definition of 'RNA, Double-Stranded'RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms. Common names: RNA, Double-Stranded; RNA, Double Stranded; Double-Stranded RNA; Double Stranded RNA |
Sunday, March 21, 2010
The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression.
13 Sep 2009 
Interleukin (IL)-18 bioactivity and dsRNA sensing by receptors of innate immunity are key components of anti-viral host defense. Despite extensive data on signal transduction activated by both pathways knowledge on cross-communication is incomplete. ... Read more...
Brain tumor immunotherapy with type-1 polarizing strategies.
30 Aug 2009 Although the safety of vaccine approaches for central nervous system (CNS) malignancies has been established in early phase clinical trials, the success of a vaccine strategy will depend critically on the ability of effector T cells to home in to ... Read more...
Activation of MDA5 requires higher-order RNA structures generated during virus infection.
3 Aug 2009 Recognition of virus presence via RIG-I (retinoic acid inducible gene I) and/or MDA5 (melanoma differentiation-associated protein 5) initiates a signaling cascade that culminates in transcription of innate response genes such as those encoding the ... Read more...
Latest indexed articles for 'RNA, Double-Stranded - Immunology'
These are the very latest articles for this heading:
- The dsRNA-mimetic poly (I:C) and IL-18 synergize for IFNgamma and TNFalpha expression. 13 Sep 2009
- Brain tumor immunotherapy with type-1 polarizing strategies. 30 Aug 2009
- Activation of MDA5 requires higher-order RNA structures generated during virus infection. 3 Aug 2009
- A nonself RNA pattern: tri-p to panhandle. 15 Jul 2009
- RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate. 14 Jul 2009
- Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus. 30 Jun 2009
- Classical swine fever virus Erns glycoprotein antagonizes induction of interferon-beta by double-stranded RNA. 30 May 2009
- B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein kinase activation. 29 Apr 2009
- Synthetic double-stranded RNAs are adjuvants for the induction of T helper 1 and humoral immune responses to human papillomavirus in rhesus macaques.
8 Apr 2009 - Double-stranded RNA-induced interferon-beta and inflammatory cytokine production modulated by hepatitis C virus serine proteases derived from patients with hepatic diseases. 6 Apr 2009
- Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. 30 Mar 2009
- Negative feedback regulation of IL-32 production by iNOS activation in response to dsRNA or influenza virus infection. 30 Mar 2009
- Inhibition of double-stranded RNA-induced TSLP in human keratinocytes by glucocorticoids.
25 Mar 2009 - Identification of an additional two-cysteine containing type I interferon in rainbow trout Oncorhynchus mykiss provides evidence of a major gene duplication event within this gene family in teleosts. 12 Mar 2009
- Lack of evidence for Litopenaeus vannamei Toll receptor (lToll) involvement in activation of sequence-independent antiviral immunity in shrimp. 7 Mar 2009
- 15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA. 23 Feb 2009
- IL-10-dependent S100A8 gene induction in monocytes/macrophages by double-stranded RNA. 13 Feb 2009
- Fish immunization using a synthetic double-stranded RNA Poly(I:C), an interferon inducer, offers protection against RGNNV, a fish nodavirus. 10 Feb 2009
- Antiviral immunity in Drosophila requires systemic RNA interference spread. 6 Feb 2009
- The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer. 29 Jan 2009
See a longer list of these articles.
Technical information about 'RNA, Double-Stranded'
Definition: RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.
Registry Number: 0
Descriptor UI: D012330
Alternative terms: RNA, Double-Stranded; RNA, Double Stranded; Double-Stranded RNA; Double Stranded RNA;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D13.444.735.490;
History Note: 80
Technical Notes: IM; /drug eff /ultrastruct permitted; DF: DSRNA