RNA, Double-Stranded - Pharmacology
Research News and Information

Sunday, November 22, 2009

Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a.

30 Aug 2009 OBJECTIVE: MicroRNA is a family of noncoding RNAs that exhibit tissue-specific or developmental stage-specific expression patterns and are associated with human diseases. MicroRNA-15a (miR-15a) is reported to induce cell apoptosis by negatively ... Read more...

PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation.

5 Jun 2009 Dendritic cells (DC) are key players in the initiation and modulation of adaptive immune responses due to their ability to acquire and present antigen and stimulate T cells. For the induction of effector T cell functions, antigen must be presented ... Read more...

Transcriptional control of behavior: engrailed knock-out changes cockroach escape trajectories.

Jun 2009 The cerci of the cockroach are covered with identified sensory hairs that detect air movements. The sensory neurons that innervate these hairs synapse with giant interneurons in the terminal ganglion that in turn synapse with interneurons and leg ... Read more...

Latest indexed articles for 'RNA, Double-Stranded - Pharmacology'

These are the very latest articles for this heading:

• Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a. 30 Aug 2009
• PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation. 5 Jun 2009
• Transcriptional control of behavior: engrailed knock-out changes cockroach escape trajectories. Jun 2009
• B-cell-activating factor expressions in salivary epithelial cells after dsRNA virus infection depends on RNA-activated protein kinase activation. 29 Apr 2009
• The immune responses in Chinese mitten crab Eriocheir sinensis challenged with double-stranded RNA. 27 Feb 2009
• IAPV, a bee-affecting virus associated with Colony Collapse Disorder can be silenced by dsRNA ingestion. 30 Jan 2009
• SHIP prevents lipopolysaccharide from triggering an antiviral response in mice. 10 Jan 2009
• Primary murine airway smooth muscle cells exposed to poly(I,C) or tunicamycin synthesize a leukocyte-adhesive hyaluronan matrix. 14 Dec 2008
• Cytokine milieu modulates release of thymic stromal lymphopoietin from human keratinocytes stimulated with double-stranded RNA. Dec 2008
• Targeting poly(I:C) to the TLR3-independent pathway boosts effector CD8 T cell differentiation through IFN-alpha/beta. 29 Nov 2008
• The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors. 18 Nov 2008
• Peroxiredoxin-1 from Schistosoma japonicum functions as a scavenger against hydrogen peroxide but not nitric oxide. 10 Nov 2008
• Prolonged gene knockdown in the tsetse fly Glossina by feeding double stranded RNA. 10 Nov 2008
• Cigarette smoke combined with Toll-like receptor 3 signaling triggers exaggerated epithelial regulated upon activation, normal T-cell expressed and secreted/CCL5 expression in chronic rhinosinusitis. 2 Nov 2008
• Application of nucleic-acid-based therapeutics for viral infections in shrimp aquaculture. 20 Oct 2008
• The clathrin-mediated endocytic pathway participates in dsRNA-induced IFN-beta production. 13 Oct 2008
• Double-stranded RNA specific to adenosine kinase and hypoxanthine-xanthine-guanine-phosphoribosyltransferase retards growth of Toxoplasma gondii. Oct 2008
• RNase-dependent inhibition of extracellular, but not intracellular, dsRNA-induced interferon synthesis by Erns of pestiviruses. 29 Sep 2008
• SEBOX is essential for early embryogenesis at the two-cell stage in the mouse. 25 Aug 2008
• Up-regulation of E-cadherin by small activating RNA inhibits cell invasion and migration in 5637 human bladder cancer cells. 22 Aug 2008

See a longer list of these articles.

Technical information about 'RNA, Double-Stranded'

Definition: RNA consisting of two strands as opposed to the more prevalent single-stranded RNA. Most of the double-stranded segments are formed from transcription of DNA by intramolecular base-pairing of inverted complementary sequences separated by a single-stranded loop. Some double-stranded segments of RNA are normal in all organisms.

Registry Number: 0

Descriptor UI: D012330

Alternative terms: RNA, Double-Stranded; RNA, Double Stranded; Double-Stranded RNA; Double Stranded RNA;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D13.444.735.490;

History Note: 80

Technical Notes: IM; /drug eff /ultrastruct permitted; DF: DSRNA