 |
RNA Interference
Research News and Information
Definition of 'RNA Interference'A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process. Common names: RNA Interference; Interference, RNA; Gene Silencing, Post-Transcriptional; Gene Silencing, Post Transcriptional; Post-Transcriptional Gene Silencings; Silencing, Post-Transcriptional Gene; Post-Transcriptional Gene Silencing; Post Transcriptional Gene Silencing; Posttranscriptional Gene Silencing |
Monday, November 23, 2009
Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1.
29 Nov 2009 
The components of the extracellular matrix (ECM) and their differential expression patterns play important roles in tissue formation. The deposition of latent TGF-beta binding proteins (LTBPs) to the ECM exhibit distinct distribution profiles. We ... Read more...
30 Oct 2009 Selective gene silencing using RNA interference (RNAi) has been shown to be an efficient method for manipulation of cellular functions. In this study, we compare three previously established methods for transfection of murine bone marrow-derived DC ... Read more...
30 Oct 2009 Growth suppressive effect of diallyl trisulfide (DATS), a promising cancer chemopreventive constituent of garlic, against cultured human cancer cells correlates with checkpoint kinase 1 (Chk1)-mediated mitotic arrest, but the fate of the cells ... Read more...
Latest indexed articles for 'RNA Interference'
These are the very latest articles for this heading:
- Matrix association of latent TGF-beta binding protein-2 (LTBP-2) is dependent on fibrillin-1. 29 Nov 2009
- A comparative study of transfection methods for RNA interference in bone marrow-derived murine dendritic cells. 30 Oct 2009
- Diallyl trisulfide-induced apoptosis in human cancer cells is linked to checkpoint kinase 1-mediated mitotic arrest. 30 Oct 2009
- Temperature entrainment of Drosophila's circadian clock involves the gene nocte and signaling from peripheral sensory tissues to the brain. 27 Oct 2009
- Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD. 10 Oct 2009
- Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome. 9 Oct 2009
- UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. 9 Oct 2009
- The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. 9 Oct 2009
- Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. 4 Oct 2009
- Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. 4 Oct 2009
- Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. 4 Oct 2009
- Proteomic and genetic approaches identify Syk as an AML target. 4 Oct 2009
- No way out for tumor cells. 4 Oct 2009
- Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton. 3 Oct 2009
- Relative contributions of chromatin and kinetochores to mitotic spindle assembly. 3 Oct 2009
- KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. 2 Oct 2009
- CDE-1 affects chromosome segregation through uridylation of CSR-1-bound siRNAs. 30 Sep 2009
- Regulating the regulators: posttranslational modifications of RNA silencing factors. 30 Sep 2009
- Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. 30 Sep 2009
- Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. 30 Sep 2009
See a longer list of these articles.
Technical information about 'RNA Interference'
Definition: A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Descriptor UI: D034622
Alternative terms: RNA Interference; Interference, RNA; Gene Silencing, Post-Transcriptional; Gene Silencing, Post Transcriptional; Post-Transcriptional Gene Silencings; Silencing, Post-Transcriptional Gene; Post-Transcriptional Gene Silencing; Post Transcriptional Gene Silencing; Posttranscriptional Gene Silencing; Gene Silencing, Posttranscriptional; Gene Silencings, Posttranscriptional; RNA Silencing; Cosuppression; Co-Suppression; Co Suppression;
Related Mesh Headings: RNA, Small Interfering; RNA-Induced Silencing Complex;
Allowable Qualifiers: drug effects; immunology; physiology; radiation effects;
Tree Number: G05.355.315.203.374.790;
History Note: 2003