RNA, Messenger - Analysis
Research News and Information

Saturday, November 21, 2009

mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death.

29 Nov 2009 BACKGROUND: Increased activity of multidrug resistance (MDR) genes has been associated with treatment failure in acute leukemias, although with controversial reports. The objective of the present study was to assess the expression profile of the ... Read more...

WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group.

29 Nov 2009 WT1 is a transcription factor that is aberrantly overexpressed in acute and chronic leukemias. Overexpression of WT1 in pediatric acute myeloid leukemia has been reported, but the prognostic significance is unclear because sample sizes in these ... Read more...

Localization of zip1 and zip4 mRNA in the adult rat brain.

30 Oct 2009 The localization of two members of the Slc39a (zip1 and zip4) family of zinc transporters was examined in the brains of adult mice. Zip1 was highly enriched in brain regions with high densities of neuronal cell bodies, including the hippocampus, ... Read more...

Latest indexed articles for 'RNA, Messenger - Analysis'

These are the very latest articles for this heading:

• mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death. 29 Nov 2009
• WT1 expression at diagnosis does not predict survival in pediatric AML: a report from the Children's Oncology Group. 29 Nov 2009
• Localization of zip1 and zip4 mRNA in the adult rat brain. 30 Oct 2009
• Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia. 30 Oct 2009
• Deficits in substance P mRNA levels in the CeA are inversely associated with alcohol-motivated responding. 30 Oct 2009
• CXCR7 is inducible by HTLV-1 Tax and promotes growth and survival of HTLV-1-infected T cells. 30 Oct 2009
• Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. 30 Oct 2009
• Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. 30 Oct 2009
• Stanniocalcin 2 promotes invasion and is associated with metastatic stages in neuroblastoma. 30 Oct 2009
• KLK6 and KLK13 predict tumor recurrence in epithelial ovarian carcinoma. 4 Oct 2009
• Underexpression of PPARgamma is associated with aneuploidy and lower differentiation of thyroid tumours of follicular origin. 29 Sep 2009
• Promoter methylation and expression analysis of MGMT in advanced pediatric brain tumors. 29 Sep 2009
• Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer. 29 Sep 2009
• Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. 29 Sep 2009
• Intravenous immunoglobulin preparations have no direct effect on B cell proliferation and immunoglobulin production. 29 Sep 2009
• Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. 29 Sep 2009
• Influence of lipopolysaccharide and interleukin-6 on RANKL and OPG expression and release in human periodontal ligament cells. 29 Sep 2009
• Detection of promoter hypermethylation of the CpG island of E-cadherin in gastric cardiac adenocarcinoma. 26 Sep 2009
• Melatonin inhibits aromatase promoter expression by regulating cyclooxygenases expression and activity in breast cancer cells. 20 Sep 2009
• Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. 20 Sep 2009

See a longer list of these articles.

Technical information about 'RNA, Messenger'

Definition: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Registry Number: 0

Descriptor UI: D012333

Alternative terms: RNA, Messenger; mRNA; Messenger RNA; RNA, Polyadenylated; Polyadenylated RNA; Poly(A)+ RNA; Poly(A) RNA; Poly(A) Tail; mRNA, Non-Polyadenylated; mRNA, Non Polyadenylated; Non-Polyadenylated mRNA; Non Polyadenylated mRNA; mRNA, Polyadenylated; RNA, Messenger, Polyadenylated; Polyadenylated mRNA; Messenger RNA, Polyadenylated; Polyadenylated Messenger RNA; RNA, Polyadenylated Messenger; Poly(A)+ mRNA;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D13.444.735.544;

Online Note: use RNA, MESSENGER (NM) to search MRNA, NON-POLYADENYLATED 1981-94, MRNA, POLYADENYLATED 1980-94, & POLY(A)+ RNA 1980-94

History Note: 65(64); MRNA, NON-POLYADENYLATED was NON-POLYADENYLATED MRNA (NM) 1981-94; MRNA, POLYADENYLATED was POLYADENYLATED MRNA (NM) 1980-94; POLY(A)+ RNA was SY to POLY(A) RNA (NM) 1980-94

Technical Notes: IM; /drug eff /ultrastruct permitted; DF: note short X ref