RNA, Messenger - Drug effects
Research News and Information

Monday, November 23, 2009

Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies.

30 Aug 2009 BACKGROUND: Constitutive activation of RhoA-dependent RhoA kinase (ROCK) signalling is known to promote cellular transformation and the ROCK inhibitor Y-27632 has the ability to suppress focus formation of RhoA transformed NIH3T3 cells. METHODS: ... Read more...

Implication of activin E in glucose metabolism: transcriptional regulation of the inhibin/activin betaE subunit gene in the liver.

20 Aug 2009 AIMS: Activin E is a newly identified member of the transforming growth factor-beta superfamily. To assess the role of activin E in glucose/energy metabolism, we investigated the transcriptional regulation of activin E in the liver. MAIN METHODS: ... Read more...

NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats.

3 Aug 2009 BACKGROUND: Inflammatory cytokines play a crucial role in the pathophysiology of traumatic brain injury (TBI), exerting either deleterious effects on the progression of tissue damage or beneficial roles during recovery and repair. NNZ-2566, a ... Read more...

Latest indexed articles for 'RNA, Messenger - Drug effects'

These are the very latest articles for this heading:

• Analogues of Y27632 increase gap junction communication and suppress the formation of transformed NIH3T3 colonies. 30 Aug 2009
• Implication of activin E in glucose metabolism: transcriptional regulation of the inhibin/activin betaE subunit gene in the liver. 20 Aug 2009
• NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. 3 Aug 2009
• Combination of cetuximab with chemoradiation, trastuzumab or MAPK inhibitors: mechanisms of sensitisation of cervical cancer cells. 2 Aug 2009
• Zonal responsiveness of the human intervertebral disc to bone morphogenetic protein-2. 30 Jul 2009
• Inhibition of inducible nitric oxide synthesis by Cimicifuga racemosa (Actaea racemosa, black cohosh) extracts in LPS-stimulated RAW 264.7 macrophages. 30 Jul 2009
• Liver X receptor agonist regulation of Th17 lymphocyte function in autoimmunity. 30 Jul 2009
• Hypoxic preconditioning-induced cerebral ischemic tolerance: role of microvascular sphingosine kinase 2. 28 Jul 2009
• 1-Cyano-2,3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic alpha,beta-unsaturated aldehyde acrolein. 22 Jul 2009
• Gene profiling of human adipose tissue during evoked inflammation in vivo. 4 Jul 2009
• Cidofovir induces an increase in levels of low-risk and high-risk HPV E6. 29 Jun 2009
• [6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells. 29 Jun 2009
• The antiproliferation effect of berbamine on k562 resistant cells by inhibiting NF-kappaB pathway. 29 Jun 2009
• Expression of toll-like receptor 9 in horse lungs. 29 Jun 2009
• Rac1 inhibition negatively regulates transcriptional activity of the amyloid precursor protein gene. 29 Jun 2009
• Targeting human gastrointestinal stromal tumor cells with a quadruplex-binding small molecule. 23 Jun 2009
• Exogenous nitric oxide inhibits shedding of ADAM17 substrates. 16 Jun 2009
• The p38 mitogen-activated protein kinase regulates 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression in human trophoblast cells through modulation of 11beta-HSD2 messenger ribonucleic acid stability. 2 Jun 2009
• Excitotoxic-mediated transcriptional decreases in HCN2 channel function increase network excitability in CA1. Jun 2009
• Protective effects of progesterone administration on axonal pathology in mice with experimental autoimmune encephalomyelitis. 31 May 2009

See a longer list of these articles.

Technical information about 'RNA, Messenger'

Definition: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Registry Number: 0

Descriptor UI: D012333

Alternative terms: RNA, Messenger; mRNA; Messenger RNA; RNA, Polyadenylated; Polyadenylated RNA; Poly(A)+ RNA; Poly(A) RNA; Poly(A) Tail; mRNA, Non-Polyadenylated; mRNA, Non Polyadenylated; Non-Polyadenylated mRNA; Non Polyadenylated mRNA; mRNA, Polyadenylated; RNA, Messenger, Polyadenylated; Polyadenylated mRNA; Messenger RNA, Polyadenylated; Polyadenylated Messenger RNA; RNA, Polyadenylated Messenger; Poly(A)+ mRNA;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D13.444.735.544;

Online Note: use RNA, MESSENGER (NM) to search MRNA, NON-POLYADENYLATED 1981-94, MRNA, POLYADENYLATED 1980-94, & POLY(A)+ RNA 1980-94

History Note: 65(64); MRNA, NON-POLYADENYLATED was NON-POLYADENYLATED MRNA (NM) 1981-94; MRNA, POLYADENYLATED was POLYADENYLATED MRNA (NM) 1980-94; POLY(A)+ RNA was SY to POLY(A) RNA (NM) 1980-94

Technical Notes: IM; /drug eff /ultrastruct permitted; DF: note short X ref