Scopolamine - Antagonists & inhibitors
Research News and Information

Monday, November 23, 2009

The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat.

6 Jun 2009 Nitric oxide (NO) is considered as an intracellular messenger in the brain. Its involvement in learning and memory processes has been proposed. Compounds that inhibit NO synthase (NOS), the key synthesizing enzyme, may inhibit cognition, while NO ... Read more...

Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice.

3 May 2009 Anemarrhena asphodeloides Bunge (AA, family Liliaceae), which primarily contains xantones, such as mangiferin, and steroidal saponins, such as timosaponin AIII and sarsasapogenin, has been used as an anti-pyretic, anti-inflammatory, anti-diabetic, ... Read more...

Mangiferin ameliorates scopolamine-induced learning deficits in mice.

30 Jan 2009 The aim of this study was to evaluate the effects of Anemarrhena asphodeloides BUNGE (AA) on cholinergic memory deficits in mice. This agent has previously been used as an antipyretic, anti-inflammatory, anti-diabetic, and antidepressant in ... Read more...

Latest indexed articles for 'Scopolamine - Antagonists & inhibitors'

These are the very latest articles for this heading:

• The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat. 6 Jun 2009
• Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. 3 May 2009
• Mangiferin ameliorates scopolamine-induced learning deficits in mice. 30 Jan 2009
• Attenuation of pharmacologically-induced attentional impairment by methylphenidate in rats. 15 Nov 2008
• Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. 29 Sep 2008
• Evaluation of the pro-cognitive effects of the AMPA receptor positive modulator, 5-(1-piperidinylcarbonyl)-2,1,3-benzoxadiazole (CX691), in the rat. 14 Sep 2008
• H3 receptor antagonists reverse delay-dependent deficits in novel object discrimination by enhancing retrieval. 20 May 2008
• The melanin-concentrating hormone1 receptor antagonists, SNAP-7941 and GW3430, enhance social recognition and dialysate levels of acetylcholine in the frontal cortex of rats. 7 May 2008
• Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice. 2 Apr 2008
• Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease. 8 Oct 2007
• Pro-cognitive effects of 5-HT6 receptor antagonists in the social recognition procedure in rats: implication of the frontal cortex. 4 Oct 2007
• 5-HT6 receptor antagonist reversal of emotional learning and prepulse inhibition deficits induced by apomorphine or scopolamine. 12 Sep 2007
• Effect of Polygala tenuifolia root extract on scopolamine-induced impairment of rat spatial cognition in an eight-arm radial maze task. 30 Aug 2007
• Prolonged effects of poly(lactic-co-glycolic acid) microsphere-containing huperzine A on mouse memory dysfunction induced by scopolamine. 27 Feb 2007
• Memory enhancing activity of Anwala churna (Emblica officinalis Gaertn.): an Ayurvedic preparation. 6 Feb 2007
• Neuropharmacological evaluation of Ginkgo biloba phytosomes in rodents. 29 Sep 2006
• Natural drug extracts for a nutritive-tonic drink, promotes the induction of long-term potentiation in rat hippocampal dentate gyrus in vivo. 9 May 2006
• Respiratory tract secretions in the dying patient: a comparison between glycopyrronium and hyoscine hydrobromide. 30 Mar 2006
• Bovine brain phosphatidylserine attenuates scopolamine induced amnesia in mice. 4 Mar 2006
• Acteoside of Callicarpa dichotoma attenuates scopolamine-induced memory impairments. 30 Dec 2005

See a longer list of these articles.

Technical information about 'Scopolamine'

Definition: An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.

Chemical name: Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-

Registry Number: 51-34-3

Descriptor UI: D012601

Alternative terms: Scopolamine; Bull Brand of Scopolamine Hydrobromide; Winzer Brand of Scopolamine Borate; Hyoscine; Hyoscine Injection BP; BP, Hyoscine Injection; Injection BP, Hyoscine; Boro-Scopol; Boro Scopol; BoroScopol; Hyocine Hydrobromide Injection BP; Kwells; Roche Brand of Scopolamine Hydrobromide; Scoburen; Renaudin Brand of Scopolamine Hydrobromide; Vorigeno; Inibisa Brand of Scopolamine Hydrobromide; Scopolamine Cooper; Cooper Brand of Scopolamine Hydrobromide; Scopolamine Hydrobromide; Hydrobromide, Scopolamine; Scopolaminum hydrobromicum; hydrobromicum, Scopolaminum; Eifelfango Brand of Scopolamine Hydrobromide; Abbott Brand of Scopolamine Hydrobromide; American Pharmaceutical Partners Brand of Scopolamine Hydrobromide; Transderm Scop; Transderm-V; Transderm V; Scopoderm TTS; Novartis Brand of Scopolamine; Novartis Consumer Health Brand of Scopolamine; Travacalm HO; Hamilton Brand of Scopolamine Hydrobromide; Isopto Hyoscine; Alcon Brand of Scopolamine Hydrobromide; Scopace; Hope Brand of Scopolamine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Mydriatics; Muscarinic Antagonists; Cholinergic Antagonists; Adjuvants, Anesthesia;

Tree Number: D02.145.074.722.900; D03.132.760.180.848; D03.132.889.848; D03.605.869.900; D04.075.080.875.099.722.900;