Scopolamine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Physostigmine-induced hypothermic response in rats and its relationship with endogenous arginine vasopressin.

29 Aug 2009 AIMS: It is well known that physostigmine (PHY) and other anticholinesterase (anti-ChE) agents induce hypothermia in rodents but little is known about the mechanism of action. Because arginine vasopressin (AVP) has been found to be an endogenous ... Read more...

Role of acetylcholine in negative patterning in turtles (Chrysemys picta).

30 Jul 2009 Turtles were run on a negative patterning task involving 2 positive elements, a key with white stripes on a black background, and a solid red key, and a compound stimulus combining the 2 elements, white stripes on a red background. Injections of ... Read more...

The inhibitory avoidance test optimized for discovery of cognitive enhancers.

30 Jul 2009 In the present article, we describe a new protocol for the inhibitory avoidance test, with a dual purpose: (1) to provide a less variable and more reliable assessment of the efficacy of potential cognitive enhancers in antagonizing ... Read more...

Latest indexed articles for 'Scopolamine - Pharmacology'

These are the very latest articles for this heading:

• Physostigmine-induced hypothermic response in rats and its relationship with endogenous arginine vasopressin. 29 Aug 2009
• Role of acetylcholine in negative patterning in turtles (Chrysemys picta). 30 Jul 2009
• The inhibitory avoidance test optimized for discovery of cognitive enhancers. 30 Jul 2009
• Effects of scopolamine on dopamine neurons in the substantia nigra: role of the pedunculopontine tegmental nucleus. 30 Jul 2009
• Selective potentiation of crossed vs. uncrossed inputs from lateral geniculate nucleus to visual cortex by the basal forebrain: potential facilitation of rodent binocularity. 21 Jul 2009
• Odor-specific habituation arises from interaction of afferent synaptic adaptation and intrinsic synaptic potentiation in olfactory cortex. 22 Jun 2009
• Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. 20 Jun 2009
• Differential novelty detection in rats selectively bred for novelty-seeking behavior. 31 May 2009
• The antidepressant effects of anticholinergic drugs. 30 May 2009
• The facilitating effect of systemic administration of Kv7/M channel blocker XE991 on LTP induction in the hippocampal CA1 area independent of muscarinic activation. 18 May 2009
• Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression. 18 May 2009
• Scopolamine induced deficits in a battery of rat cognitive tests: comparisons of sensitivity and specificity. 29 Apr 2009
• Muscarinic receptor blockade in ventral hippocampus and prelimbic cortex impairs memory for socially transmitted food preference. 29 Apr 2009
• A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease. 7 Apr 2009
• Comparison studies of tacrine and bis7-tacrine on the suppression of scopolamine-induced behavioral changes and inhibition of acetylcholinesterase in mice. 6 Apr 2009
• Spontaneous release of acetylcholine from autonomic nerves in the bladder. Apr 2009
• JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. 31 Mar 2009
• The role of the AT4 and cholinergic systems in the Nucleus Basalis Magnocellularis (NBM): effects on spatial memory. 23 Mar 2009
• The amygdala modulates morphine-induced state-dependent memory retrieval via muscarinic acetylcholine receptors. 7 Mar 2009
• Alternating low frequency stimulation of medial septal and commissural fibers induces NMDA-dependent, long-lasting potentiation of hippocampal synapses in urethane-anesthetized rats. 27 Feb 2009

See a longer list of these articles.

Technical information about 'Scopolamine'

Definition: An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.

Chemical name: Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-

Registry Number: 51-34-3

Descriptor UI: D012601

Alternative terms: Scopolamine; Bull Brand of Scopolamine Hydrobromide; Winzer Brand of Scopolamine Borate; Hyoscine; Hyoscine Injection BP; BP, Hyoscine Injection; Injection BP, Hyoscine; Boro-Scopol; Boro Scopol; BoroScopol; Hyocine Hydrobromide Injection BP; Kwells; Roche Brand of Scopolamine Hydrobromide; Scoburen; Renaudin Brand of Scopolamine Hydrobromide; Vorigeno; Inibisa Brand of Scopolamine Hydrobromide; Scopolamine Cooper; Cooper Brand of Scopolamine Hydrobromide; Scopolamine Hydrobromide; Hydrobromide, Scopolamine; Scopolaminum hydrobromicum; hydrobromicum, Scopolaminum; Eifelfango Brand of Scopolamine Hydrobromide; Abbott Brand of Scopolamine Hydrobromide; American Pharmaceutical Partners Brand of Scopolamine Hydrobromide; Transderm Scop; Transderm-V; Transderm V; Scopoderm TTS; Novartis Brand of Scopolamine; Novartis Consumer Health Brand of Scopolamine; Travacalm HO; Hamilton Brand of Scopolamine Hydrobromide; Isopto Hyoscine; Alcon Brand of Scopolamine Hydrobromide; Scopace; Hope Brand of Scopolamine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Mydriatics; Muscarinic Antagonists; Cholinergic Antagonists; Adjuvants, Anesthesia;

Tree Number: D02.145.074.722.900; D03.132.760.180.848; D03.132.889.848; D03.605.869.900; D04.075.080.875.099.722.900;