Scopolamine
Research News and Information

Saturday, November 21, 2009

Epidemic of poisoning caused by scopolamine disguised as Rohypnol tablets.

30 Oct 2009 OBJECTIVE: An epidemic of scopolamine poisonings occurred in Oslo in 2008 among users of illicit drugs, caused by fake Rohypnol pills. The clinical features, diagnostic process, and handling of the epidemic are presented. METHODS: Suspected cases of ... Read more...

Physostigmine-induced hypothermic response in rats and its relationship with endogenous arginine vasopressin.

29 Aug 2009 AIMS: It is well known that physostigmine (PHY) and other anticholinesterase (anti-ChE) agents induce hypothermia in rodents but little is known about the mechanism of action. Because arginine vasopressin (AVP) has been found to be an endogenous ... Read more...

NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade.

19 Aug 2009 The non-steroidal anti-inflammatory drug flurbiprofen is a selective amyloid lowering agent which has been studied clinically in Alzheimer's disease. HCT-1026 is an ester prodrug of flurbiprofen incorporating a nitrate carrier moiety that in vivo ... Read more...

Latest indexed articles for 'Scopolamine'

These are the very latest articles for this heading:

• Epidemic of poisoning caused by scopolamine disguised as Rohypnol tablets. 30 Oct 2009
• Physostigmine-induced hypothermic response in rats and its relationship with endogenous arginine vasopressin. 29 Aug 2009
• NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade. 19 Aug 2009
• Role of acetylcholine in negative patterning in turtles (Chrysemys picta). 30 Jul 2009
• Uterine peristalsis in women with repeated IVF failures: possible therapeutic effect of hyoscine bromide. 30 Jul 2009
• The inhibitory avoidance test optimized for discovery of cognitive enhancers. 30 Jul 2009
• Modafinil as a potential motion sickness countermeasure. 30 Jul 2009
• Nausea and vomiting after office-based anesthesia. 30 Jul 2009
• Effects of scopolamine on dopamine neurons in the substantia nigra: role of the pedunculopontine tegmental nucleus. 30 Jul 2009
• Selective potentiation of crossed vs. uncrossed inputs from lateral geniculate nucleus to visual cortex by the basal forebrain: potential facilitation of rodent binocularity. 21 Jul 2009
• Odor-specific habituation arises from interaction of afferent synaptic adaptation and intrinsic synaptic potentiation in olfactory cortex. 22 Jun 2009
• Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials. 20 Jun 2009
• The nitric oxide (NO) donor molsidomine antagonizes scopolamine and L-NAME-induced performance deficits in a spatial memory task in the rat. 6 Jun 2009
• Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery. 4 Jun 2009
• Differential novelty detection in rats selectively bred for novelty-seeking behavior. 31 May 2009
• The antidepressant effects of anticholinergic drugs. 30 May 2009
• Effects of DA-6034 on aqueous tear fluid secretion and conjunctival goblet cell proliferation. 30 May 2009
• Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice. 25 May 2009
• The facilitating effect of systemic administration of Kv7/M channel blocker XE991 on LTP induction in the hippocampal CA1 area independent of muscarinic activation. 18 May 2009
• Nelumbo nucifera semen extract improves memory in rats with scopolamine-induced amnesia through the induction of choline acetyltransferase expression. 18 May 2009

See a longer list of these articles.

Technical information about 'Scopolamine'

Definition: An alkaloid from SOLANACEAE, especially DATURA and SCOPOLIA. Scopolamine and its quaternary derivatives act as antimuscarinics like ATROPINE, but may have more central nervous system effects. Among the many uses are as an anesthetic premedication, in URINARY INCONTINENCE, in MOTION SICKNESS, as an antispasmodic, and as a mydriatic and cycloplegic.

Chemical name: Benzeneacetic acid, alpha-(hydroxymethyl)-, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (7(S)-(1alpha,2beta,4beta,5alpha,7beta))-

Registry Number: 51-34-3

Descriptor UI: D012601

Alternative terms: Scopolamine; Bull Brand of Scopolamine Hydrobromide; Winzer Brand of Scopolamine Borate; Hyoscine; Hyoscine Injection BP; BP, Hyoscine Injection; Injection BP, Hyoscine; Boro-Scopol; Boro Scopol; BoroScopol; Hyocine Hydrobromide Injection BP; Kwells; Roche Brand of Scopolamine Hydrobromide; Scoburen; Renaudin Brand of Scopolamine Hydrobromide; Vorigeno; Inibisa Brand of Scopolamine Hydrobromide; Scopolamine Cooper; Cooper Brand of Scopolamine Hydrobromide; Scopolamine Hydrobromide; Hydrobromide, Scopolamine; Scopolaminum hydrobromicum; hydrobromicum, Scopolaminum; Eifelfango Brand of Scopolamine Hydrobromide; Abbott Brand of Scopolamine Hydrobromide; American Pharmaceutical Partners Brand of Scopolamine Hydrobromide; Transderm Scop; Transderm-V; Transderm V; Scopoderm TTS; Novartis Brand of Scopolamine; Novartis Consumer Health Brand of Scopolamine; Travacalm HO; Hamilton Brand of Scopolamine Hydrobromide; Isopto Hyoscine; Alcon Brand of Scopolamine Hydrobromide; Scopace; Hope Brand of Scopolamine;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Mydriatics; Muscarinic Antagonists; Cholinergic Antagonists; Adjuvants, Anesthesia;

Tree Number: D02.145.074.722.900; D03.132.760.180.848; D03.132.889.848; D03.605.869.900; D04.075.080.875.099.722.900;