Serine - Pharmacology
Research News and Information

Sunday, November 22, 2009

Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors.

14 Sep 2009 Toluene, a widely used and commonly abused organic solvent, causes a variety of behavioral disturbances in both humans and animals. In this study, the effects of toluene on locomotor activity, motor coordination, and passive avoidance learning, ... Read more...

The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases.

30 Jul 2009 The enzyme serine palmitoyltransferase (SPT) catalyzes the rate-limiting step in the de novo synthesis of sphingolipids. Previously the mammalian SPT was described as a heterodimer composed of two subunits, SPTLC1 and SPTLC2. Recently we identified ... Read more...

In vivo [(123)I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats.

29 Jun 2009 Disturbances of activity of the glutamatergic neurotransmitter system in the brain are present in many neuropsychiatric disorders. The N-methyl-D-aspartate (NMDA) receptor is the most abundant receptor of the glutamatergic system. In the ... Read more...

Latest indexed articles for 'Serine - Pharmacology'

These are the very latest articles for this heading:

• Acute neurobehavioral effects of toluene: involvement of dopamine and NMDA receptors. 14 Sep 2009
• The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases. 30 Jul 2009
• In vivo [(123)I]CNS-1261 binding to D-serine-activated and MK801-blocked NMDA receptors: A storage phosphor imaging study in rats. 29 Jun 2009
• The ObgE/CgtA GTPase influences the stringent response to amino acid starvation in Escherichia coli. 21 Jun 2009
• Antinociceptive effects of systemic lidocaine: involvement of the spinal glycinergic system. 22 Apr 2009
• Hepatic cystathionine beta-synthase activity does not increase in response to methionine supplementation in rats fed a low casein diet: association with plasma homocysteine concentrations. 30 Mar 2009
• Glutamatergic transmission in hydra: NMDA/D-serine affects the electrical activity of the body and tentacles of Hydra vulgaris (Cnidaria, Hydrozoa). 30 Mar 2009
• Glycine transporter blockade ameliorates motor ataxia in a mouse model of spinocerebellar atrophy. 5 Mar 2009
• Cell cycle synchronization of Escherichia coli using the stringent response, with fluorescence labeling assays for DNA content and replication. 22 Feb 2009
• Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonists. 16 Feb 2009
• Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine. 10 Feb 2009
• D-Serine exposure resulted in gene expression changes implicated in neurodegenerative disorders and neuronal dysfunction in male Fischer 344 rats. 9 Feb 2009
• Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium. 26 Jan 2009
• Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: chemistry and biology. 30 Dec 2008
• Genetic inactivation of D-amino acid oxidase enhances extinction and reversal learning in mice. 28 Dec 2008
• Human polycomb 2 protein is a SUMO E3 ligase and alleviates substrate-induced inhibition of cystathionine beta-synthase sumoylation. 22 Dec 2008
• D-serine induces lipid and protein oxidative damage and decreases glutathione levels in brain cortex of rats. 22 Dec 2008
• The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. 14 Dec 2008
• High-casein diet suppresses guanidinoacetic acid-induced hyperhomocysteinemia and potentiates the hypohomocysteinemic effect of serine in rats. 5 Dec 2008
• L-Serine lowers while glycine increases blood pressure in chronic L-NAME-treated and spontaneously hypertensive rats. 29 Nov 2008

See a longer list of these articles.

Technical information about 'Serine'

Definition: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.

Chemical name: L-Serine

Registry Number: 56-45-1

Descriptor UI: D012694

Alternative terms: Serine; L-Serine; L Serine;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.125.154.800; D12.125.837;