Serotonin - Deficiency
Research News and Information

Sunday, November 22, 2009

Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development.

17 Aug 2009 Central serotonin (5-HT) neurons modulate many vital brain functions, including respiratory control. Whether breathing depends critically on 5-HT neurons, or whether their influence is excitatory or inhibitory, remains controversial. Here we show ... Read more...

Growth retardation and altered autonomic control in mice lacking brain serotonin.

9 Jun 2009 Serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (TPH), TPH1 and TPH2. By genetically ablating TPH2, we created mice (Tph2(-/-)) that lack serotonin in the central nervous system. Surprisingly, these mice can be born ... Read more...

Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex.

4 May 2009 Prefrontal cortex (PFC) is critical for self-ordered response sequencing. Patients with frontal lobe damage are impaired on response sequencing tasks, and increased blood flow has been reported in ventrolateral and dorsolateral PFC in subjects ... Read more...

Latest indexed articles for 'Serotonin - Deficiency'

These are the very latest articles for this heading:

• Transgenic mice lacking serotonin neurons have severe apnea and high mortality during development. 17 Aug 2009
• Effect of serotonin deficiency on the immune system development in the rat. 29 Jun 2009
• Growth retardation and altered autonomic control in mice lacking brain serotonin. 9 Jun 2009
• Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex. 4 May 2009
• The brain 5-HT4 receptor binding is down-regulated in the Flinders Sensitive Line depression model and in response to paroxetine administration. 21 Mar 2009
• Dopaminergic and serotoninergic deficiencies in young adult rats prenatally exposed to the bacterial lipopolysaccharide. 19 Feb 2009
• A phosphodiesterase inhibitor, cilomilast, enhances cAMP activity to restore conditioned odor preference memory after serotonergic depletion in the neonate rat. 18 Feb 2009
• Autoresuscitation responses to hypoxia-induced apnea are delayed in newborn 5-HT-deficient Pet-1 homozygous mice. 10 Feb 2009
• Effects of 5-HT depletion in the frontal cortex or nucleus accumbens on response inhibition measured in the 5-choice serial reaction time test and on a DRL schedule. 4 Feb 2009
• Three distinct amine receptors operating at different levels within the locomotory circuit are each essential for the serotonergic modulation of chemosensation in Caenorhabditis elegans. 2 Feb 2009
• Phosphodiesterase 5 inhibitors prevent 3,4-methylenedioxymethamphetamine-induced 5-HT deficits in the rat. 30 Jan 2009
• Effect of central serotonin depletion on 5-HT receptor-mediated vasomotor responses in the middle meningeal artery of anaesthetized rats. 30 Dec 2008
• Dietary tryptophan restriction in rats triggers astrocyte cytoskeletal hypertrophy in hippocampus and amygdala. 8 Dec 2008
• The role of serotonin in viral hepatitis - depletion of plasma tryptophan as a potential option to reduce virus persistence and immunopathology? 23 Nov 2008
• Interaction between defects in ventilatory and thermoregulatory control in mice lacking 5-HT neurons. 13 Aug 2008
• Enhanced contextual fear memory in central serotonin-deficient mice. 9 Aug 2008
• A new track for understanding the pathogenesis of multiple sclerosis: from the perspective of early developmental deficit caused by the potential 5-HT deficiency in individuals in high-latitude areas. 29 Jul 2008
• Quantitative image analysis reveals distinct structural transitions during aging in Caenorhabditis elegans tissues. 28 Jul 2008
• Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. 28 Jul 2008
• The effects of an anabolic androgenic steroid and low serotonin on social and non-social behaviors in male rats. 26 Jul 2008

See a longer list of these articles.

Technical information about 'Serotonin'

Definition: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

Chemical name: 1H-Indol-5-ol, 3-(2-aminoethyl)-

Registry Number: 50-67-9

Descriptor UI: D012701

Alternative terms: Serotonin; 5-Hydroxytryptamine; 5 Hydroxytryptamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; Enteramine; Hippophaine; Hydroxytryptamine;

Related Mesh Headings: Receptors, Serotonin; Serotonin Agents; Serotonin Syndrome;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Pharmacological Action: Serotonin Agents;

Tree Number: D02.092.211.215.801.852; D03.438.473.914.814; D23.469.050.650;

Online Note: use SEROTONIN to search HYDROXYTRYPTAMINE 1975-92

History Note: HYDROXYTRYPTAMINE was see SEROTONIN 1975-92

Technical Notes: /antag = SEROTONIN ANTAGONISTS but consider also SEROTONIN UPTAKE INHIBITORS