Serotonin - Metabolism
Research News and Information

Saturday, November 21, 2009

MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.

29 Sep 2009 3,4-Methylenedioxymethamphetamine (MDMA) is a drug of abuse worldwide and a selective serotonin (5-HT) neurotoxin. An important factor in the risk of drug abuse and relapse is stress. Although multiple parallels exist between MDMA abuse and stress, ... Read more...

Development of the Wireless Instantaneous Neurotransmitter Concentration System for intraoperative neurochemical monitoring using fast-scan cyclic voltammetry.

29 Sep 2009 OBJECT: Emerging evidence supports the hypothesis that modulation of specific central neuronal systems contributes to the clinical efficacy of deep brain stimulation (DBS) and motor cortex stimulation (MCS). Real-time monitoring of the neurochemical ... Read more...

Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans.

21 Sep 2009 The neuromodulator serotonin has been implicated in a large number of affective and executive functions, but its precise contribution to motivation remains unclear. One influential hypothesis has implicated serotonin in aversive processing; another ... Read more...

Latest indexed articles for 'Serotonin - Metabolism'

These are the very latest articles for this heading:

• Deciphering the interaction of the corticotropin-releasing factor and serotonin brain systems in anxiety-related disorders. 2 Nov 2009
• MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning. 29 Sep 2009
• Development of the Wireless Instantaneous Neurotransmitter Concentration System for intraoperative neurochemical monitoring using fast-scan cyclic voltammetry. 29 Sep 2009
• Reconciling the role of serotonin in behavioral inhibition and aversion: acute tryptophan depletion abolishes punishment-induced inhibition in humans. 21 Sep 2009
• Spontaneous activity in the developing mouse midbrain driven by an external pacemaker. 13 Sep 2009
• Serotonergic modulation of basal ganglia circuits: complexity and therapeutic opportunities. 13 Sep 2009
• Serotonin targets inhibitory synapses to induce modulation of network functions. 10 Sep 2009
• The use of viral gene transfer in studies of brainstem noradrenergic and serotonergic neurons. 10 Sep 2009
• Differential regulation of the central neural cardiorespiratory system by metabotropic neurotransmitters. 10 Sep 2009
• A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure. 2 Sep 2009
• Mechanisms by which the serotonergic system inhibits micturition in rats. 31 Aug 2009
• Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats. 30 Aug 2009
• The role of serotonin in nonnormative risky choice: the effects of tryptophan supplements on the "reflection effect" in healthy adult volunteers. 30 Aug 2009
• Mammalian prenatal development: the influence of maternally derived molecules. 30 Aug 2009
• Alteration of synaptic transmission in the hippocampal-mPFC pathway during extinction trials of context-dependent fear memory in juvenile rat stress models. 30 Aug 2009
• Effects of chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. 30 Aug 2009
• Serotonergic-postsynaptic receptors modulate gripping-induced immobility episodes in male taiep rats. 30 Aug 2009
• Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts. 30 Aug 2009
• Embryonic and adult stem cells promote raphespinal axon outgrowth and improve functional outcome following spinal hemisection in mice. 25 Aug 2009
• Serotonergic innervation of the caudal spinal stump in rats after complete spinal transection: effect of olfactory ensheathing glia. 18 Aug 2009

See a longer list of these articles.

Technical information about 'Serotonin'

Definition: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.

Chemical name: 1H-Indol-5-ol, 3-(2-aminoethyl)-

Registry Number: 50-67-9

Descriptor UI: D012701

Alternative terms: Serotonin; 5-Hydroxytryptamine; 5 Hydroxytryptamine; 3-(2-Aminoethyl)-1H-indol-5-ol; 5-HT; Enteramine; Hippophaine; Hydroxytryptamine;

Related Mesh Headings: Receptors, Serotonin; Serotonin Agents; Serotonin Syndrome;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Pharmacological Action: Serotonin Agents;

Tree Number: D02.092.211.215.801.852; D03.438.473.914.814; D23.469.050.650;

Online Note: use SEROTONIN to search HYDROXYTRYPTAMINE 1975-92

History Note: HYDROXYTRYPTAMINE was see SEROTONIN 1975-92

Technical Notes: /antag = SEROTONIN ANTAGONISTS but consider also SEROTONIN UPTAKE INHIBITORS