Serotonin Agents - Toxicity
Research News and Information

Saturday, November 21, 2009

Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells.

17 Jun 2009 There is substantial evidence supporting a hypertrophic action of serotonin [5-hydroxytryptamine (5-HT)] in cardiomyocytes. However, little is known about the mechanisms involved. We previously demonstrated that 5-HT-induced hypertrophy depends, in ... Read more...

Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex.

4 May 2009 Prefrontal cortex (PFC) is critical for self-ordered response sequencing. Patients with frontal lobe damage are impaired on response sequencing tasks, and increased blood flow has been reported in ventrolateral and dorsolateral PFC in subjects ... Read more...

Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons.

13 Apr 2009 The medullary 5-HT system has potent effects on heart rate and breathing in adults. We asked whether this system mitigates the respiratory instability and bradycardias frequently occurring during the neonatal period. 5,7-Dihydroxytryptamine ... Read more...

Latest indexed articles for 'Serotonin Agents - Toxicity'

These are the very latest articles for this heading:

• Dose-dependent activation of distinct hypertrophic pathways by serotonin in cardiac cells. 17 Jun 2009
• Response disengagement on a spatial self-ordered sequencing task: effects of regionally selective excitotoxic lesions and serotonin depletion within the prefrontal cortex. 4 May 2009
• Severe spontaneous bradycardia associated with respiratory disruptions in rat pups with fewer brain stem 5-HT neurons. 13 Apr 2009
• Amphetamine-induced abnormal movements occur independently of both transplant- and host-derived serotonin innervation following neural grafting in a rat model of Parkinson's disease. 6 Apr 2009
• Investigation of the pruritogenic effects of histamine, serotonin, tryptase, substance P and interleukin-2 in healthy dogs. 19 Jan 2009
• Long-term behavioral consequences of prenatal MDMA exposure. 29 Dec 2008
• Acute behavioural and neurotoxic effects of MDMA plus cocaine in adolescent mice. 25 Jul 2008
• Positron emission tomographic studies of brain dopamine and serotonin transporters in abstinent (+/-)3,4-methylenedioxymethamphetamine ("ecstasy") users: relationship to cognitive performance. 25 Jul 2008
• MDMA treatment 6 months earlier attenuates the effects of CP-94,253, a 5-HT1B receptor agonist, on motor control but not sleep inhibition. 30 Jun 2008
• Auditory event-related potentials (P3) and cognitive performance in recreational ecstasy polydrug users: evidence from a 12-month longitudinal study. 24 Jun 2008
• Effects of serotonin depletion on the hippocampal GR/MR and BDNF expression during the stress adaptation. 10 Jun 2008
• 5-hydroxytryptamine (5HT)-induced valvulopathy: compositional valvular alterations are associated with 5HT2B receptor and 5HT transporter transcript changes in Sprague-Dawley rats. Jun 2008
• When administered to rats in a cold environment, 3,4-methylenedioxymethamphetamine reduces brown adipose tissue thermogenesis and increases tail blood flow: effects of pretreatment with 5-HT1A and dopamine D2 antagonists. 30 Apr 2008
• Influence of 5,7-dihydroxytryptamine lesions of the rat fornix-fimbria and cingulum bundles on spontaneous activity in an aversive maze. 29 Apr 2008
• The role of the dorsomedial part of the prefrontal cortex serotonergic innervation in rat responses to the aversively conditioned context: behavioral, biochemical and immunocytochemical studies. 14 Apr 2008
• Phencyclidine-induced locomotor hyperactivity is enhanced in mice after stereotaxic brain serotonin depletion. 9 Apr 2008
• Neuropeptide Y protects retinal neural cells against cell death induced by ecstasy. Mar 2008
• Developmental effects of 3,4-methylenedioxymethamphetamine: a review. 28 Feb 2008
• Tolerance to 3,4-methylenedioxymethamphetamine in rats exposed to single high-dose binges. 10 Jan 2008
• Restoration of 3,4-methylenedioxymethamphetamine-induced 5-HT depletion by the administration of L-5-hydroxytryptophan. 10 Jul 2007

See a longer list of these articles.

Technical information about 'Serotonin Agents'

Definition: Drugs used for their effects on serotonergic systems. Among these are drugs that affect serotonin receptors, the life cycle of serotonin, and the survival of serotonergic neurons.

Registry Number: 0

Descriptor UI: D018490

Alternative terms: Serotonin Agents; Agents, Serotonin; Serotonin Drugs; Drugs, Serotonin; Serotonergic Drugs; Drugs, Serotonergic; Serotonergic Agents; Agents, Serotonergic;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.850; D27.505.696.577.850;

History Note: 95; SEROTONIN NEURON AGENTS (NON MESH) was heading 1995

Technical Notes: GEN or unspecified; prefer specific groups or specific drugs