Serotonin Antagonists
Research News and Information

Saturday, November 21, 2009

Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.

6 Oct 2009 Stereodefined trisubstituted cyclopropanes bearing naphthyloxy, thiophenyl, and (N-methylamino)methyl groups were synthesized in enantiopure form employing asymmetric cyclopropanation of (E)- and (Z)-allylic alcohols as the key step. In vitro assays ... Read more...

Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists.

6 Oct 2009 Changing the N,N-(dimethylamino)ethyl side chain in the N-[3-(aminoethyl)inden-5-yl]sulfonamide 5-HT(6) serotonin receptor agonists 1 by a conformationally rigid guanylhydrazone moiety at the indene 3-position led to the identification of the title ... Read more...

Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion.

29 Sep 2009 Substantial evidence suggests that pharmacological manipulations of neural serotonin pathways influence ingestive behaviors. Despite the known role of the nucleus accumbens in directing appetitive and consummatory behavior, there has been little ... Read more...

Latest indexed articles for 'Serotonin Antagonists'

These are the very latest articles for this heading:

• Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters. 6 Oct 2009
• Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. 6 Oct 2009
• Case records of the Massachusetts General Hospital. Case 31-2009. A 26-year-old man with abdominal distention and shock. 6 Oct 2009
• Selective serotonin receptor stimulation of the medial nucleus accumbens causes differential effects on food intake and locomotion. 29 Sep 2009
• Differential effects of topiramate on prefrontal glutamatergic transmission when combined with raclopride or clozapine. 29 Sep 2009
• Mechanisms by which the serotonergic system inhibits micturition in rats. 31 Aug 2009
• Emerging drugs for insomnia: new frontiers for old and novel targets. 30 Aug 2009
• [The efficacy of indisetron hydrochloride for the management of chemotherapy-induced nausea and vomiting for lung cancer] 30 Aug 2009
• Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats. 30 Aug 2009
• Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells. 30 Aug 2009
• Effects of chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. 30 Aug 2009
• Serotonergic-postsynaptic receptors modulate gripping-induced immobility episodes in male taiep rats. 30 Aug 2009
• Chronic treatment of hydroxytryptamine type 2a receptor antagonist sarpogrelate hydrochloride modulates the vasoreactivity of serotonin in experimental rabbit vein grafts. 30 Aug 2009
• [Update: Current clinical developments in pulmonary hypertension] 26 Aug 2009
• [Update: Preclinical developments for the treatment of pulmonary arterial hypertension] 26 Aug 2009
• In vivo evidence that constitutive activity of serotonin2C receptors in the medial prefrontal cortex participates in the control of dopamine release in the rat nucleus accumbens: differential effects of inverse agonist versus antagonist. 20 Aug 2009
• Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. 11 Aug 2009
• The bovine mammary gland expresses multiple functional isoforms of serotonin receptors. 2 Aug 2009
• Serotonergic modulation of crayfish hindgut. 30 Jul 2009
• Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Serotonin Antagonists'

Definition: Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonin agonists.

Registry Number: 0

Descriptor UI: D012702

Alternative terms: Serotonin Antagonists; Antagonists, Serotonin; 5-Hydroxytryptamine Antagonists; 5 Hydroxytryptamine Antagonists; Antagonists, 5-HT; Antagonists, 5 HT; 5-HT Antagonists; 5 HT Antagonists; Antagonists, 5-Hydroxytryptamine; Antagonists, 5 Hydroxytryptamine; Antiserotonergic Agents; Agents, Antiserotonergic; Serotonin Blockaders; Blockaders, Serotonin;

Related Mesh Headings: Serotonin Uptake Inhibitors;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications;

Tree Number: D27.505.519.625.850.850; D27.505.696.577.850.850;

Online Note: search SEROTONIN /antagonists & inhibitors 1968-77 & SEROTONIN 1966-67

History Note: 78,64-67

Technical Notes: GEN or unspecified; prefer specifics; differentiate from SEROTONIN UPTAKE INHIBITORS: read MeSH definition; do not confuse with SEROTONIN AGONISTS; DF: SEROTONIN ANTAG