Serotonin Plasma Membrane Transport Proteins - Deficiency
Research News and Information

Sunday, November 22, 2009

Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation.

30 Mar 2009 The effects of serotonin (5-HT) on tumor growth are inconsistent. We investigated whether a decreased level of 5-HT affected tumor growth using 5-HT transporter knockout (5-HTT(-/-)) mice, which showed 5-HT depletion. When cancer cells were injected ... Read more...

Reward circuitry is perturbed in the absence of the serotonin transporter.

18 Mar 2009 The serotonin transporter (SERT) modulates the entire serotonergic system in the brain and influences both the dopaminergic and norepinephrinergic systems. These three systems are intimately involved in normal physiological functioning of the brain ... Read more...

Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice.

26 Jan 2009 There has been much interest in the relative importance of dopamine and serotonin transporters in the abuse-related-effects of cocaine. We tested the hypotheses that mice lacking the dopamine transporter (DAT(-/-)), the serotonin transporter ... Read more...

Latest indexed articles for 'Serotonin Plasma Membrane Transport Proteins - Deficiency'

These are the very latest articles for this heading:

• Depletion of serotonin and selective inhibition of 2B receptor suppressed tumor angiogenesis by inhibiting endothelial nitric oxide synthase and extracellular signal-regulated kinase 1/2 phosphorylation. 30 Mar 2009
• Reward circuitry is perturbed in the absence of the serotonin transporter. 18 Mar 2009
• Dramatically decreased cocaine self-administration in dopamine but not serotonin transporter knock-out mice. 26 Jan 2009
• Imaging elevated brain arachidonic acid signaling in unanesthetized serotonin transporter (5-HTT)-deficient mice. 12 Jan 2009
• Expression of the serotonin transporter (SERT) gene during mouse development. 30 Aug 2008
• Neurochemical, behavioral, and physiological effects of pharmacologically enhanced serotonin levels in serotonin transporter (SERT)-deficient mice. 17 Aug 2008
• Lack of the serotonin transporter does not prevent mineralocorticoid hypertension in rat and mouse. 5 Jun 2008
• Serotonin transporter dosage modulates long-term decision-making in rat and human. 24 Apr 2008
• Lasting syndrome of depression produced by reduction in serotonin uptake during postnatal development: evidence from sleep, stress, and behavior. 31 Mar 2008
• Vascular reactivity, 5-HT uptake, and blood pressure in the serotonin transporter knockout rat. 6 Feb 2008
• Expression analysis for inverted effects of serotonin transporter inactivation. 20 Jan 2008
• Serotonin transporter deficiency in rats improves inhibitory control but not behavioural flexibility. 29 Sep 2007
• Receptor mediation of exaggerated responses to serotonin-enhancing drugs in serotonin transporter (SERT)-deficient mice. 25 Jul 2007
• Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system. 28 Apr 2007
• Chronic blockade or constitutive deletion of the serotonin transporter reduces operant responding for food reward. 12 Mar 2007
• Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. 15 Jan 2007
• Gender-dependent regulation of G-protein-gated inwardly rectifying potassium current in dorsal raphe neurons in knock-out mice devoid of the 5-hydroxytryptamine transporter. 30 Oct 2006
• Are serotonin transporter knockout mice 'depressed'?: hypoactivity but no anhedonia. 19 Aug 2006
• Ethanol inhibits clearance of brain serotonin by a serotonin transporter-independent mechanism. 12 Jun 2006
• Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice. 18 Mar 2006

See a longer list of these articles.

Technical information about 'Serotonin Plasma Membrane Transport Proteins'

Definition: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.

Registry Number: 0

Descriptor UI: D050486

Alternative terms: Serotonin Plasma Membrane Transport Proteins; 5HT Transporter; Neurotransmitter Transport Proteins, Serotonin-Specific; Neurotransmitter Transport Proteins, Serotonin Specific; Sodium-Dependent Serotonin Transporter; Serotonin Transporter, Sodium-Dependent; Sodium Dependent Serotonin Transporter; Transporter, Sodium-Dependent Serotonin; Serotonin Plasma Membrane Transporter Proteins; Serotonin Transporter; Transporter, Serotonin; SERT Proteins; 5-Hydroxytryptamine Plasma Membrane Transport Protein; 5 Hydroxytryptamine Plasma Membrane Transport Protein; Neurotransmitter Transporters, Serotonin-Specific; Neurotransmitter Transporters, Serotonin Specific; Serotonin-Specific Neurotransmitter Transporters; Transporters, Serotonin-Specific Neurotransmitter; Serotonectin; Serotonin Transporter, Platelets; Platelets Serotonin Transporter; Transporter, Platelets Serotonin; Platelet Serotonin Transporter; Serotonin Transporter, Platelet; Transporter, Platelet Serotonin;

Related Mesh Headings: Receptors, Serotonin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.530.450.625.311; D12.776.157.530.562.374.875; D12.776.543.585.450.625.374; D12.776.543.585.562.374.875;

History Note: 2006(1992)