Serotonin Plasma Membrane Transport Proteins
Research News and Information

Saturday, November 21, 2009

Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.

30 Oct 2009 CONTEXT: The 5-HTTLPR polymorphism in the promoter region of the serotonin transporter gene (SLC6A4) has been found to moderate several categories of emotional response after stressful life events. Previous studies generally focused on its effect on ... Read more...

Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters.

6 Oct 2009 Stereodefined trisubstituted cyclopropanes bearing naphthyloxy, thiophenyl, and (N-methylamino)methyl groups were synthesized in enantiopure form employing asymmetric cyclopropanation of (E)- and (Z)-allylic alcohols as the key step. In vitro assays ... Read more...

MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.

29 Sep 2009 3,4-Methylenedioxymethamphetamine (MDMA) is a drug of abuse worldwide and a selective serotonin (5-HT) neurotoxin. An important factor in the risk of drug abuse and relapse is stress. Although multiple parallels exist between MDMA abuse and stress, ... Read more...

Latest indexed articles for 'Serotonin Plasma Membrane Transport Proteins'

These are the very latest articles for this heading:

• Gene-environment interactions and depression. 2 Nov 2009
• Gene-environment interactions and depression. 2 Nov 2009
• Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations. 30 Oct 2009
• Synthesis of 1,1-[1-naphthyloxy-2-thiophenyl]-2-methylaminomethylcyclopropanes and their evaluation as inhibitors of serotonin, norepinephrine, and dopamine transporters. 6 Oct 2009
• MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning. 29 Sep 2009
• 1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones: potent, selective, and orally efficacious norepinephrine reuptake inhibitors. 22 Sep 2009
• Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease. 21 Sep 2009
• Huntington disease: a tale of two genes. 21 Sep 2009
• Striatal expression of a calmodulin fragment improved motor function, weight loss, and neuropathology in the R6/2 mouse model of Huntington's disease. 14 Sep 2009
• [Serotonin receptor gene polymorphism and analgesic sensitivity] 30 Aug 2009
• The human serotonin transporter gene explains why some populations are more optimistic? 30 Aug 2009
• Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms? 30 Aug 2009
• Candidate genes involved in neural plasticity and the risk for attention-deficit hyperactivity disorder: a meta-analysis of 8 common variants. 30 Aug 2009
• Genetic studies of drug response and side effects in the STAR*D study, part 2. 30 Aug 2009
• Vulnerability to depression: what is the role of stress genes in gene x environment interaction? 30 Aug 2009
• Impact of the tri-allelic serotonin transporter polymorphism on the white-matter tract connecting the amygdala and the prefrontal cortex. 24 Aug 2009
• Genetics and psychiatry: time for a multidimensional approach? 19 Aug 2009
• In vivo characterization of a series of 18F-diaryl sulfides (18F-2-(2'-((dimethylamino)methyl)-4'-(fluoroalkoxy)phenylthio)benzenamine) for PET imaging of the serotonin transporter. 16 Aug 2009
• Drug-induced fibrotic valvular heart disease. 13 Aug 2009
• Serotonin transporter availability in the amygdala and bed nucleus of the stria terminalis predicts anxious temperament and brain glucose metabolic activity. 10 Aug 2009

See a longer list of these articles.

Technical information about 'Serotonin Plasma Membrane Transport Proteins'

Definition: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.

Registry Number: 0

Descriptor UI: D050486

Alternative terms: Serotonin Plasma Membrane Transport Proteins; 5HT Transporter; Neurotransmitter Transport Proteins, Serotonin-Specific; Neurotransmitter Transport Proteins, Serotonin Specific; Sodium-Dependent Serotonin Transporter; Serotonin Transporter, Sodium-Dependent; Sodium Dependent Serotonin Transporter; Transporter, Sodium-Dependent Serotonin; Serotonin Plasma Membrane Transporter Proteins; Serotonin Transporter; Transporter, Serotonin; SERT Proteins; 5-Hydroxytryptamine Plasma Membrane Transport Protein; 5 Hydroxytryptamine Plasma Membrane Transport Protein; Neurotransmitter Transporters, Serotonin-Specific; Neurotransmitter Transporters, Serotonin Specific; Serotonin-Specific Neurotransmitter Transporters; Transporters, Serotonin-Specific Neurotransmitter; Serotonectin; Serotonin Transporter, Platelets; Platelets Serotonin Transporter; Transporter, Platelets Serotonin; Platelet Serotonin Transporter; Serotonin Transporter, Platelet; Transporter, Platelet Serotonin;

Related Mesh Headings: Receptors, Serotonin;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.530.450.625.311; D12.776.157.530.562.374.875; D12.776.543.585.450.625.374; D12.776.543.585.562.374.875;

History Note: 2006(1992)