Serotonin Uptake Inhibitors - Pharmacology
Research News and Information

Monday, November 23, 2009

In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand.

29 Sep 2009 This study evaluated the in vitro and in vivo characteristics of a new dopamine transporter (DAT) radioligand, [(18)F]fluoroethyl(FE)PE2I, by autoradiography from postmortem human brain and by positron emission tomography (PET) in three cynomolgus ... Read more...

Parathyroid surgery and methylene blue: a review with guidelines for safe intraoperative use.

29 Sep 2009 Methylene blue has been used to help facilitate parathyroid surgery for over 30 years. Its use has been widely considered both safe and cost effective. Twenty-six cases of a toxic metabolic encephalopathy, however, have been reported with its use. ... Read more...

Antidepressant medication use during breastfeeding.

30 Aug 2009 We performed an electronic search by using MEDLINE, PreMEDLINE, Current Contents, Biological Abstracts, and PsycINFO from June 2002 to December 2008 using the following terms: "antidepressant drugs", "antidepressive agents", "human milk", ... Read more...

Latest indexed articles for 'Serotonin Uptake Inhibitors - Pharmacology'

These are the very latest articles for this heading:

• Tamoxifen, antidepressants, and CYP2D6: the conundrum continues. 29 Sep 2009
• In vitro autoradiography and in vivo evaluation in cynomolgus monkey of [18F]FE-PE2I, a new dopamine transporter PET radioligand. 29 Sep 2009
• Parathyroid surgery and methylene blue: a review with guidelines for safe intraoperative use. 29 Sep 2009
• Antidepressant medication use during breastfeeding. 30 Aug 2009
• Impact of acute tryptophan depletion on mood and eating-related urges in bulimic and nonbulimic women. 30 Aug 2009
• Synthesis, potency, and in vivo evaluation of 2-piperazin-1-ylquinoline analogues as dual serotonin reuptake inhibitors and serotonin 5-HT1A receptor antagonists. 11 Aug 2009
• Corticotropin-releasing factor, serotonin, and sex: keys to the castle of depressive illness. 30 Jul 2009
• Effects of selective serotonin reuptake inhibitor therapy on endothelial function and inflammatory markers in patients with coronary heart disease. 27 Jul 2009
• Structure-based discovery of low molecular weight compounds that stimulate neurite outgrowth and substitute for nerve growth factor. 15 Jul 2009
• An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant. 14 Jul 2009
• Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A. 13 Jul 2009
• Serotonin released from amacrine neurons is scavenged and degraded in bipolar neurons in the retina. 6 Jul 2009
• The effect of olanzapine pretreatment on acute cocaine toxicity in mice. 29 Jun 2009
• Serotonergic modulation of the trigeminocardiac reflex neurotransmission to cardiac vagal neurons in the nucleus ambiguus. 22 Jun 2009
• Repeated exposure to MDMA provides neuroprotection against subsequent MDMA-induced serotonin depletion in brain. 21 Jun 2009
• Neurosteroids modulate compulsive and persistent behavior in rodents: implications for obsessive-compulsive disorder. 19 Jun 2009
• Use of latency to immobility improves detection of antidepressant-like activity in the behavioral despair test in the mouse. 19 Jun 2009
• Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin. 19 Jun 2009
• Delirium in a patient with toxic flecainide plasma concentrations: the role of a pharmacokinetic drug interaction with paroxetine. 14 Jun 2009
• Serotonin rising. 9 Jun 2009

See a longer list of these articles.

Technical information about 'Serotonin Uptake Inhibitors'

Definition: Compounds that specifically inhibit the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. These agents have been used in treatment of depression, panic disorder, obsessive-compulsive behavior, and alcoholism, as analgesics, and to treat obesity and bulimia. Many of the ADRENERGIC UPTAKE INHIBITORS also inhibit serotonin uptake; they are not included here.

Registry Number: 0

Descriptor UI: D017367

Alternative terms: Serotonin Uptake Inhibitors; Uptake Inhibitors, 5-HT; Uptake Inhibitors, 5 HT; 5-HT Uptake Inhibitors; 5 HT Uptake Inhibitors; Inhibitors, 5-Hydroxytryptamine Uptake; Inhibitors, 5 Hydroxytryptamine Uptake; Uptake Inhibitors, 5-Hydroxytryptamine; Uptake Inhibitors, 5 Hydroxytryptamine; Inhibitors, Serotonin Reuptake; Reuptake Inhibitors, Serotonin; Serotonin Reuptake Inhibitors; Inhibitors, Serotonin Uptake; Uptake Inhibitors, Serotonin; Inhibitors, 5-HT Uptake; Inhibitors, 5 HT Uptake; 5-Hydroxytryptamine Uptake Inhibitors; 5 Hydroxytryptamine Uptake Inhibitors;

Related Mesh Headings: Antidepressive Agents, Second-Generation; Adrenergic Uptake Inhibitors;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D27.505.519.625.600.850; D27.505.519.625.850.900; D27.505.696.577.600.850; D27.505.696.577.850.900;

History Note: 93

Technical Notes: GEN or unspecified; prefer specifics; do not confuse with SEROTONIN ANTAGONISTS; DF: SEROTONIN UPTAKE INHIB