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Sex Hormone-Binding Globulin - Metabolism
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Definition of 'Sex Hormone-Binding Globulin'

A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

Common names: Sex Hormone-Binding Globulin; Globulin, Sex Hormone-Binding; Hormone-Binding Globulin, Sex; Sex Hormone Binding Globulin; Testosterone-Estradiol Binding Globulin; Binding Globulin, Testosterone-Estradiol; Globulin, Testosterone-Estradiol Binding; Testosterone Estradiol Binding Globulin

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Friday, March 12, 2010

Sex hormones and frailty in older men: the osteoporotic fractures in men (MrOS) study.

6 Sep 2009 CONTEXT: As men age, the prevalence of frailty increases whereas levels of androgens decline. Little is known about the relation between these factors. OBJECTIVE: The aim of this study was to assess cross-sectional and longitudinal associations of ... Read more...


Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health In Men Study.

4 Aug 2009 OBJECTIVE: Insulin resistance is associated with metabolic syndrome and type 2 diabetes, representing a risk factor for cardiovascular disease. This relationship may be modulated to some extent by age-related changes in sex hormone status. We ... Read more...


Insulin resistance and C-reactive protein in preeclampsia.

30 Jul 2009 Preeclampsia is referred to as the "disease of the theories" because of the multiple hypotheses proposed to explain is occurrence. Despite considerable research, the causes of preeclampsia remain unclear. Preeclampsia is likely to be multifactorial ... Read more...

 

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Technical information about 'Sex Hormone-Binding Globulin'

Definition: A glycoprotein migrating as a beta-globulin. Its molecular weight, 52,000 or 95,000-115,000, indicates that it exists as a dimer. The protein binds testosterone, dihydrotestosterone, and estradiol in the plasma. Sex hormone-binding protein has the same amino acid sequence as ANDROGEN-BINDING PROTEIN. They differ by their sites of synthesis and post-translational oligosaccharide modifications.

Registry Number: 0

Descriptor UI: D012738

Alternative terms: Sex Hormone-Binding Globulin; Globulin, Sex Hormone-Binding; Hormone-Binding Globulin, Sex; Sex Hormone Binding Globulin; Testosterone-Estradiol Binding Globulin; Binding Globulin, Testosterone-Estradiol; Globulin, Testosterone-Estradiol Binding; Testosterone Estradiol Binding Globulin; Sex Steroid-Binding Protein; Sex Steroid Binding Protein; Steroid-Binding Protein, Sex;

Related Mesh Headings: Androgen-Binding Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.124.790.223.800; D12.776.157.762; D12.776.377.715.182.800;

Online Note: use SEX HORMONE-BINDING GLOBULIN (NM) to search SEX-STEROID-BINDING PROTEIN 1981-91; use SEX HORMONE-BINDING GLOBULIN to search ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN 1977-92

History Note: 77; SEX STEROID-BINDING PROTEIN was SEX-STEROID-BINDING PROTEIN (NM) 1981-91; ESTRADIOL-BINDING GLOBULIN & TESTOSTERONE-BINDING GLOBULIN were see SEX HORMONE-BINDING GLOBULIN 1977-92

Technical Notes: does not refer to all sex hormones: refers to a specific protein in the blood binding only testosterone or estradiol; for other sex hormone-binding globulins consider ANDROGEN-BINDING PROTEIN & PROGESTERONE-BINDING GLOBULIN; DF: SHBG

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