Sialic Acids - Metabolism
Research News and Information

Sunday, November 22, 2009

YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid.

9 Sep 2009 The nanATEK-yhcH, yjhATS, and yjhBC operons in Escherichia coli are coregulated by environmental N-acetylneuraminic acid, the most prevalent sialic acid in nature. Here we show that YjhS (NanS) is a probable 9-O-acetyl N-acetylneuraminic acid ... Read more...

A close look at human IgG sialylation and subclass distribution after lectin fractionation.

30 Aug 2009 Polyspecific human IgG preparations are indicated for the treatment of primary immunodeficiency disorders associated with defects in humoral immunity. In addition, intraveneous IgG (IVIG) is used to treat patients with autoimmune and systemic ... Read more...

Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases.

29 Aug 2009 Hemagglutinin esterases (HEs), closely related envelope glycoproteins in influenza C and corona- and toroviruses, mediate reversible attachment to O-acetylated sialic acids (Sias). They do so by acting both as lectins and as receptor-destroying ... Read more...

Latest indexed articles for 'Sialic Acids - Metabolism'

These are the very latest articles for this heading:

• YjhS (NanS) is required for Escherichia coli to grow on 9-O-acetylated N-acetylneuraminic acid. 9 Sep 2009
• A close look at human IgG sialylation and subclass distribution after lectin fractionation. 30 Aug 2009
• Structural basis for ligand and substrate recognition by torovirus hemagglutinin esterases. 29 Aug 2009
• Ajit Varki: on the origin of maladies. Interviewed by Amy Maxmen. 29 Aug 2009
• Sialic acids as regulators of molecular and cellular interactions. 17 Aug 2009
• N-methyl-D-aspartate receptor independent changes in expression of polysialic acid-neural cell adhesion molecule despite blockade of homosynaptic long-term potentiation and heterosynaptic long-term depression in the awake freely behaving rat dentate gyrus. 11 Aug 2009
• Enigmatic central canal contacting cells: immature neurons in "standby mode"? 10 Aug 2009
• Resveratrol attenuates 1,2-dimethylhydrazine (DMH) induced glycoconjugate abnormalities during various stages of colon carcinogenesis. 30 Jul 2009
• Innovations in host and microbial sialic acid biosynthesis revealed by phylogenomic prediction of nonulosonic acid structure. 26 Jul 2009
• NCAM and polysialyltransferase profiles match dopaminergic marker gene expression but polysialic acid is dispensable for development of the midbrain dopamine system. 6 Jul 2009
• Polysialic acid governs T-cell development by regulating progenitor access to the thymus. 6 Jul 2009
• Brain development needs sugar: the role of polysialic acid in controlling NCAM functions. 29 Jun 2009
• Probing a sialyltransferase's recognition domain to prepare alpha(2,8)-linked oligosialosides and analogs. 17 Jun 2009
• Beta4 tubulin identifies a primitive cell source for oligodendrocytes in the mammalian brain. 15 Jun 2009
• The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. 13 Jun 2009
• Streptococcus mitis phage-encoded adhesins mediate attachment to {alpha}2-8-linked sialic acid residues on platelet membrane gangliosides. 6 Jun 2009
• A lectin from the Chinese bird-hunting spider binds sialic acids. 4 Jun 2009
• Interruption of beta-catenin signaling reduces neurogenesis in Alzheimer's disease. 18 May 2009
• Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific marker. 16 May 2009
• A polysialic acid mimetic peptide promotes functional recovery in a mouse model of spinal cord injury. 11 May 2009

See a longer list of these articles.

Technical information about 'Sialic Acids'

Definition: A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.

Registry Number: 0

Descriptor UI: D012794

Alternative terms: Sialic Acids; Acids, Sialic; N-Acetylneuraminic Acids; Acids, N-Acetylneuraminic; N Acetylneuraminic Acids;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.241.081.844.562.668; D02.241.511.902.562.668; D09.067.687.668; D09.811.589.668;

Online Note: search NEURAMINIC ACIDS 1966-74

History Note: 75; was see under NEURAMINIC ACIDS 1963-74