Signal Transduction - Drug effects
Research News and Information

Monday, November 23, 2009

Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells.

29 Nov 2009 Bradykinin (BK) is a potent modulator of biological processes in the retina, and retinal pigment epithelial cells (RPE) and the regulation of glutamate are believed to be important in the pathogenesis of diabetic retinopathy. However, the mechanism ... Read more...

Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling.

29 Nov 2009 The role of OxLDL in the generation and progression of atherosclerosis is well admitted. In addition, it is well known that atherosclerosis is often accompanied by perturbations in bone remodeling, resulting in osteoporosis. In the current studies, ... Read more...

Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment.

29 Nov 2009 The osteo-anabolic effects of intermittent parathyroid hormone (PTH) treatment require insulin-like growth factor (IGF) signaling through the IGF-I receptor. A major downstream target of the IGF-I receptor (via Akt) is the mammalian target of ... Read more...

Latest indexed articles for 'Signal Transduction - Drug effects'

These are the very latest articles for this heading:

• Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells. 29 Nov 2009
• Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. 29 Nov 2009
• Rapamycin impairs trabecular bone acquisition from high-dose but not low-dose intermittent parathyroid hormone treatment. 29 Nov 2009
• The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Nov 2009
• Attenuation of subarachnoid hemorrhage-induced apoptotic cell death with 17 beta-estradiol. Laboratory investigation. 30 Oct 2009
• Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. 30 Oct 2009
• NF-kappaB independent activation of a series of proinflammatory genes by hydrogen sulfide. 30 Oct 2009
• Isoflurane-induced changes in righting response and breathing are modulated by RGS proteins. 30 Oct 2009
• Propofol inhibits aquaporin 4 expression through a protein kinase C-dependent pathway in an astrocyte model of cerebral ischemia/reoxygenation. 30 Oct 2009
• Cyr61 downmodulation potentiates the anticancer effects of zoledronic acid in androgen-independent prostate cancer cells. 30 Oct 2009
• Leptin attenuates hypoxia/reoxygenation-induced activation of the intrinsic pathway of apoptosis in rat H9c2 cells. 30 Oct 2009
• Cytokines and signaling pathways regulating matrix metalloproteinase-9 (MMP-9) expression in corneal epithelial cells. 30 Oct 2009
• NAG7 promotes human nasopharyngeal carcinoma invasion through inhibition of estrogen receptor alpha and up-regulation of JNK2/AP-1/MMP1 pathways. 30 Oct 2009
• Cl-IB-MECA enhances TRAIL-induced apoptosis via the modulation of NF-kappaB signalling pathway in thyroid cancer cells. 30 Oct 2009
• EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1. 21 Oct 2009
• IRAK1-independent pathways required for the interleukin-1-stimulated activation of the Tpl2 catalytic subunit and its dissociation from ABIN2. 21 Oct 2009
• Proteomic analysis uncovers novel actions of the neurosecretory protein VGF in nociceptive processing. 19 Oct 2009
• The time course of dopamine transmission in the ventral tegmental area. 19 Oct 2009
• Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. 19 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009

See a longer list of these articles.

Technical information about 'Signal Transduction'

Definition: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor UI: D015398

Alternative terms: Signal Transduction; Signal Transductions; Transduction, Signal; Transductions, Signal; Signal Transduction Systems; Signal Transduction System; System, Signal Transduction; Systems, Signal Transduction; Signal Transduction Pathways; Pathway, Signal Transduction; Pathways, Signal Transduction; Signal Transduction Pathway; Receptor-Mediated Signal Transduction; Receptor-Mediated Signal Transductions; Signal Transduction, Receptor-Mediated; Signal Transductions, Receptor-Mediated; Receptor Mediated Signal Transduction; Signal Pathways; Pathway, Signal; Pathways, Signal; Signal Pathway;

Related Mesh Headings: Ion Channels;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.800; G02.149.115.800; G04.299.880;

History Note: 89