Signal Transduction - Physiology
Research News and Information

Saturday, November 21, 2009

Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells.

29 Nov 2009 Bradykinin (BK) is a potent modulator of biological processes in the retina, and retinal pigment epithelial cells (RPE) and the regulation of glutamate are believed to be important in the pathogenesis of diabetic retinopathy. However, the mechanism ... Read more...

Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling.

29 Nov 2009 The role of OxLDL in the generation and progression of atherosclerosis is well admitted. In addition, it is well known that atherosclerosis is often accompanied by perturbations in bone remodeling, resulting in osteoporosis. In the current studies, ... Read more...

Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway.

29 Nov 2009 Calcium/calmodulin-dependent protein kinase IV (CaMKIV) plays a key role in the regulation of calcium-dependent gene expression. The expression of CaMKIV and the activation of CREB regulated genes are involved in memory and neuronal survival. We ... Read more...

Latest indexed articles for 'Signal Transduction - Physiology'

These are the very latest articles for this heading:

• Both B1R and B2R act as intermediate signaling molecules in high glucose-induced stimulation of glutamate uptake in ARPE cells. 29 Nov 2009
• Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signaling. 29 Nov 2009
• Calcium/calmodulin-dependent protein kinase type IV is a target gene of the Wnt/beta-catenin signaling pathway. 29 Nov 2009
• Requirement of a dynein light chain in TGFbeta/Smad3 signaling. 29 Nov 2009
• Inositol 1,4,5-trisphosphate 3-kinase a functions as a scaffold for synaptic Rac signaling. 2 Nov 2009
• The nitric oxide/cGMP pathway tunes the thermosensitivity of swimming motor patterns in Xenopus laevis tadpoles. 2 Nov 2009
• Structure elucidation and preliminary assessment of hydrolase activity of PqsE, the Pseudomonas quinolone signal (PQS) response protein. Nov 2009
• A flavin cofactor-binding PAS domain regulates c-di-GMP synthesis in AxDGC2 from Acetobacter xylinum. Nov 2009
• Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival. 30 Oct 2009
• C-terminal region-dependent change of antibody-binding to the Eighth Reelin repeat reflects the signaling activity of Reelin. 30 Oct 2009
• Phospholipid transfer protein reduces phosphorylation of tau in human neuronal cells. 30 Oct 2009
• Role of p38 MAPK pathway in induction of iNOS expression in neutrophils and peripheral blood mononuclear cells in patients with squamous cell carcinoma of the oral cavity. 30 Oct 2009
• Odontoblast TRP channels and thermo/mechanical transmission. 30 Oct 2009
• Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. 30 Oct 2009
• Time is of the essence: vascular implications of the circadian clock. 25 Oct 2009
• EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1. 21 Oct 2009
• Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation. 21 Oct 2009
• Design of proteolytically stable RI-anchoring disruptor peptidomimetics for in vivo studies of anchored type I protein kinase A-mediated signalling. 21 Oct 2009
• The time course of dopamine transmission in the ventral tegmental area. 19 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009

See a longer list of these articles.

Technical information about 'Signal Transduction'

Definition: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

Descriptor UI: D015398

Alternative terms: Signal Transduction; Signal Transductions; Transduction, Signal; Transductions, Signal; Signal Transduction Systems; Signal Transduction System; System, Signal Transduction; Systems, Signal Transduction; Signal Transduction Pathways; Pathway, Signal Transduction; Pathways, Signal Transduction; Signal Transduction Pathway; Receptor-Mediated Signal Transduction; Receptor-Mediated Signal Transductions; Signal Transduction, Receptor-Mediated; Signal Transductions, Receptor-Mediated; Receptor Mediated Signal Transduction; Signal Pathways; Pathway, Signal; Pathways, Signal; Signal Pathway;

Related Mesh Headings: Ion Channels;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G02.111.087.800; G02.149.115.800; G04.299.880;

History Note: 89