Sirtuins - Drug effects
Research News and Information

Sunday, November 22, 2009

Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation.

14 Jun 2009 OBJECTIVES: The aim of this study was to compare the effects of paclitaxel, sirolimus, and everolimus on the senescent phenotype in human endothelial cells, and to further investigate possible involvement of mammalian sirtuin 1 (Sirt1) ... Read more...

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.

12 May 2009 Changes in gene expression contribute to the long-lasting regulation of the brain's reward circuitry seen in drug addiction; however, the specific genes regulated and the transcriptional mechanisms underlying such regulation remain poorly ... Read more...

Resveratrol induces mitochondrial biogenesis in endothelial cells.

6 May 2009 Pathways that regulate mitochondrial biogenesis are potential therapeutic targets for the amelioration of endothelial dysfunction and vascular disease. Resveratrol was shown to impact mitochondrial function in skeletal muscle and the liver, but its ... Read more...

Latest indexed articles for 'Sirtuins - Drug effects'

These are the very latest articles for this heading:

• Sirolimus and everolimus induce endothelial cellular senescence via sirtuin 1 down-regulation: therapeutic implication of cilostazol after drug-eluting stent implantation. 14 Jun 2009
• Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. 12 May 2009
• Resveratrol induces mitochondrial biogenesis in endothelial cells. 6 May 2009
• Sirtuin activators. 30 Mar 2009
• Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction. 27 Feb 2009
• A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases. 30 Oct 2008
• Alcohol-induced alterations in hepatic microtubule dynamics can be explained by impaired histone deacetylase 6 function. 30 Oct 2008
• Resveratrol and novel potent activators of SIRT1: effects on aging and age-related diseases. 29 Sep 2008
• Chemical probes for histone-modifying enzymes. 29 Sep 2008
• The mechanism of hyperoside protection of ECV-304 cells against tert-butyl hydroperoxide-induced injury. 14 Jun 2008
• Modulation of SIRT1 expression in different neurodegenerative models and human pathologies. May 2008
• Resveratrol in prevention and treatment of common clinical conditions of aging. 30 Dec 2007
• Trans-resveratrol: a magical elixir of eternal youth? 30 Dec 2007
• Modulation of sirtuins: new targets for antiageing. 30 Dec 2007
• Myristica fragrans Houtt. methanolic extract induces apoptosis in a human leukemia cell line through SIRT1 mRNA downregulation. 30 Oct 2007
• Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury. 29 Sep 2007
• Does resveratrol activate yeast Sir2 in vivo? 30 Jul 2007
• [Cheers !] 30 Jan 2007
• SIR2: a potential target for calorie restriction mimetics. 2 Jan 2007
• Design and synthesis of compounds that extend yeast replicative lifespan. 3 Dec 2006

See a longer list of these articles.

Technical information about 'Sirtuins'

Definition: A homologous family of proteins that includes the NAD-dependent protein deacetylases which deacetylate proteins by catalyzing the formation of O-acetyl-ADP-ribose from the ADP-RIBOSE moiety (of NAD) and the acetyl group that is being removed from the protein. Sir2p, from Saccharomyces cerevisiae, is the founding member and the family includes other homologs (HSTs - homologs of Sir Two). Some HISTONE DEACETYLASES (the Sir2-like HDACs) belong to this family of proteins.

Registry Number: EC 3.5.1.-

Descriptor UI: D037761

Alternative terms: Sirtuins; Silent Mating Type Information Regulator 2-like Proteins; Silent Mating Type Information Regulator 2 like Proteins; Sir2-like Proteins; Sir2 like Proteins; NAD-Dependent Protein Deacetylases; Deacetylases, NAD-Dependent Protein; NAD Dependent Protein Deacetylases; Protein Deacetylases, NAD-Dependent; Sir2-like Deacetylases; Deacetylases, Sir2-like; Sir2 like Deacetylases;

Related Mesh Headings: Histone Deacetylases; Silent Information Regulator Proteins, Saccharomyces cerevisiae;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D08.811.277.087.831; D08.811.913.400.725.115.845;

History Note: 2003

Technical Notes: note specific sirtuins in SCR