Small Molecule Libraries
Research News and Information

Sunday, November 22, 2009

Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins.

6 Oct 2009 Molecular disruption of the lipid carrier AFABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. Because small molecule inhibitors may be efficacious in defining the mechanism(s) of AFABP/aP2 action, a ... Read more...

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation.

29 Sep 2009 The development of highly active antiretroviral therapy (HAART) to treat individuals infected with HIV-1 has dramatically improved patient outcomes, but HAART still fails to cure the infection. The latent viral reservoir in resting CD4+ T cells is a ... Read more...

Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers.

22 Sep 2009 Adenosine A(2A) (A(2A)R) and dopamine D(2) (D(2)R) receptors mediate the antagonism between adenosinergic and dopaminergic transmission in striatopallidal GABAergic neurons and are pharmacological targets for the treatment of Parkinson's disease. ... Read more...

Latest indexed articles for 'Small Molecule Libraries'

These are the very latest articles for this heading:

• Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. 6 Oct 2009
• Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation. 29 Sep 2009
• Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers. 22 Sep 2009
• Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals. 16 Sep 2009
• Small molecule inhibitors of yeast pre-mRNA splicing. 16 Sep 2009
• Chemical genetic screening in the zebrafish embryo. 8 Sep 2009
• Identification of specific small molecule ligands for stem loop 3 ribonucleic acid of the packaging signal Psi of human immunodeficiency virus-1. 8 Sep 2009
• On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and Lacmoid. 6 Sep 2009
• Target profiling of small molecules by chemical proteomics. 30 Aug 2009
• Protease dimer formation disrupted. 30 Aug 2009
• Antibiotics for emerging pathogens. 26 Aug 2009
• Small-molecule multidrug resistance-associated protein 1 inhibitor reversan increases the therapeutic index of chemotherapy in mouse models of neuroblastoma. 2 Aug 2009
• Design, synthesis and selection of DNA-encoded small-molecule libraries. 31 Jul 2009
• Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75. 30 Jul 2009
• Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis. 30 Jul 2009
• Flexible alignment of small molecules using the penalty method. 30 Jul 2009
• Tunable machine vision-based strategy for automated annotation of chemical databases. 30 Jul 2009
• Regenerative pharmacology for diabetes mellitus. 30 Jul 2009
• Statistical methods for analysis of high-throughput RNA interference screens. 30 Jul 2009
• Directed evolution drives the next generation of biocatalysts. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Small Molecule Libraries'

Definition: Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening analysis of the gene function, protein interaction, cellular processing, biochemical pathways, or other chemical interactions.

Registry Number: 0

Descriptor UI: D054852

Alternative terms: Small Molecule Libraries; Libraries, Small Molecule; Molecule Libraries, Small; Molecular Libraries, Small; Libraries, Small Molecular; Small Molecular Libraries; Chemical Libraries; Libraries, Chemical;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; chemical synthesis; classification; diagnostic use; economics; history; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; chemistry; contraindications;

Tree Number: D27.720.470.765;

History Note: 2008