 |
Small Ubiquitin-Related Modifier Proteins - Antagonists & inhibitors
Research News and Information
Definition of 'Small Ubiquitin-Related Modifier Proteins'A class of structurally related proteins of 12-20 kDa in size. They covalently modify specific proteins in a manner analogous to UBIQUITIN. Common names: Small Ubiquitin-Related Modifier Proteins; Small Ubiquitin Related Modifier Proteins; Ubiquitin-Related Modifier Protein, Small; Ubiquitin Related Modifier Protein, Small; Sentrins; Sentrin Proteins; SUMO Proteins |
Monday, November 23, 2009
26 Mar 2009 
Human cells derived from nevoid basal carcinoma syndrome (NBCCS) patients show increased levels of DNA synthesis activity after X-ray irradiation which is suggested to be casually related to reduction in cellular amounts of small ubiquitin-like ... Read more...
Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate.
25 Feb 2009 Protein modification by small ubiquitin-related modifier proteins (SUMOs) controls diverse cellular functions. Dysregulation of SUMOylation or deSUMOylation processes has been implicated in the development of cancer and neurodegenerative diseases. ... Read more...
Mel-18 interacts with RanGAP1 and inhibits its sumoylation.
12 Aug 2008 Our previous results showed that the polycomb protein mel-18 binds to a protein called HSF2 and inhibits HSF2 sumoylation, thereby functioning as an anti-SUMO E3 factor. This study also suggested that mel-18 regulates the sumoylation of other ... Read more...
Latest indexed articles for 'Small Ubiquitin-Related Modifier Proteins - Antagonists & inhibitors'
These are the very latest articles for this heading:
- Nm23-H1 is responsible for SUMO-2-involved DNA synthesis induction after X-ray irradiation in human cells. 26 Mar 2009
- Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. 25 Feb 2009
- Mel-18 interacts with RanGAP1 and inhibits its sumoylation. 12 Aug 2008
- Viral control of the SUMO pathway: Gam1, a model system. 29 Nov 2007
- SUSP1 antagonizes formation of highly SUMO2/3-conjugated species.
23 Sep 2006 - Drosophila Ulp1, a nuclear pore-associated SUMO protease, prevents accumulation of cytoplasmic SUMO conjugates. 2 Aug 2004
- SUMO in cancer--wrestlers wanted. 29 Apr 2002
See a longer list of these articles.
Technical information about 'Small Ubiquitin-Related Modifier Proteins'
Definition: A class of structurally related proteins of 12-20 kDa in size. They covalently modify specific proteins in a manner analogous to UBIQUITIN.
Registry Number: 0
Descriptor UI: D025841
Alternative terms: Small Ubiquitin-Related Modifier Proteins; Small Ubiquitin Related Modifier Proteins; Ubiquitin-Related Modifier Protein, Small; Ubiquitin Related Modifier Protein, Small; Sentrins; Sentrin Proteins; SUMO Proteins;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.947.249;
History Note: 2002