 |
Small Ubiquitin-Related Modifier Proteins - Metabolism
Research News and Information
Definition of 'Small Ubiquitin-Related Modifier Proteins'A class of structurally related proteins of 12-20 kDa in size. They covalently modify specific proteins in a manner analogous to UBIQUITIN. Common names: Small Ubiquitin-Related Modifier Proteins; Small Ubiquitin Related Modifier Proteins; Ubiquitin-Related Modifier Protein, Small; Ubiquitin Related Modifier Protein, Small; Sentrins; Sentrin Proteins; SUMO Proteins |
Sunday, November 22, 2009
22 Sep 2009 
To unravel the roles of LXRs in inflammation and immunity, we examined the function of LXRs in development of IFN-gamma-mediated inflammation using cultured rat brain astrocytes. LXR ligands inhibit neither STAT1 phosphorylation nor STAT1 ... Read more...
Summon SUMO to wrestle with inflammation.
22 Sep 2009 In this issue of Molecular Cell, Lee et al. (2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain ... Read more...
9 Sep 2009 Siz1 is a founding member of the Siz/PIAS RING family of SUMO E3 ligases. The X-ray structure of an active Siz1 ligase revealed an elongated tripartite architecture comprised of an N-terminal PINIT domain, a central zinc-containing RING-like SP-RING ... Read more...
Latest indexed articles for 'Small Ubiquitin-Related Modifier Proteins - Metabolism'
These are the very latest articles for this heading:
- Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes. 22 Sep 2009
- Summon SUMO to wrestle with inflammation. 22 Sep 2009
- Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. 9 Sep 2009
- Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I. 22 Aug 2009
- Endocytic control of ion channel density as a target for cardiovascular disease. 22 Aug 2009
- Protein kinases mediate ligand-independent derepression of sumoylated progesterone receptors in breast cancer cells. 15 Aug 2009
- A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9. 14 Aug 2009
- A toolbox approach to high-throughput TR-FRET-based SUMOylation and DeSUMOylation assays. 30 Jul 2009
- The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. 30 Jul 2009
- Proteomic revelation: SUMO changes partners when the heat is on. 26 Jul 2009
- SUMOylation of nuclear actin. 25 Jul 2009
- Enhanced SUMOylation of proteins containing a SUMO-interacting motif by SUMO-Ubc9 fusion. 23 Jul 2009
- SUMO association with repressor complexes, emerging routes for transcriptional control. 15 Jul 2009
- SUMO modification regulates the transcriptional activity of FLASH. 14 Jul 2009
- Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity. 11 Jul 2009
- Kruppel-associated box domain-associated protein-1 as a latency regulator for Kaposi's sarcoma-associated herpesvirus and its modulation by the viral protein kinase. 5 Jul 2009
- Solution structure of SUMO from Trypanosoma brucei and its interaction with Ubc9.
29 Jun 2009 - Troponin I and Tropomyosin regulate chromosomal stability and cell polarity. 28 Jun 2009
- Characterization of SENP7, a SUMO-2/3-specific isopeptidase. 24 Jun 2009
- Ebola Zaire virus blocks type I interferon production by exploiting the host SUMO modification machinery.
24 Jun 2009
See a longer list of these articles.
Technical information about 'Small Ubiquitin-Related Modifier Proteins'
Definition: A class of structurally related proteins of 12-20 kDa in size. They covalently modify specific proteins in a manner analogous to UBIQUITIN.
Registry Number: 0
Descriptor UI: D025841
Alternative terms: Small Ubiquitin-Related Modifier Proteins; Small Ubiquitin Related Modifier Proteins; Ubiquitin-Related Modifier Protein, Small; Ubiquitin Related Modifier Protein, Small; Sentrins; Sentrin Proteins; SUMO Proteins;
Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;
Tree Number: D12.776.947.249;
History Note: 2002