Sodium - Pharmacology
Research News and Information

Monday, November 23, 2009

Effects of high-K(+), Na(+)-deficient solution on contractility of the smooth muscles of the porcine trachea.

30 Aug 2009 A high-K(+), Na(+)-deficient (isosmotic 154 mM K(+) and 0 mM Na(+); I-154 K(+)) solution induced contraction followed by gradual relaxation of the smooth muscles of the porcine trachea, while hyperosmotic addition of 65 mM KCl (H-65 K(+)) induced a ... Read more...

To switch or not to switch: the effects of potassium and sodium ions on alpha-poly-L-glutamate conformations in aqueous solutions.

10 Aug 2009 Molecular dynamics simulations demonstrate that differences in the interaction of sodium and potassium with the carboxylate side chains of alpha-poly-L-glutamate (alpha-PGA) have a dramatic effect on the conformational properties of the polypeptide. ... Read more...

The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters.

9 Aug 2009 Glutamate transporters maintain low synaptic concentrations of neurotransmitter by coupling uptake to flux of other ions. Their transport cycle consists of two separate translocation steps, namely cotransport of glutamic acid with three Na(+) ... Read more...

Latest indexed articles for 'Sodium - Pharmacology'

These are the very latest articles for this heading:

• Effects of high-K(+), Na(+)-deficient solution on contractility of the smooth muscles of the porcine trachea. 30 Aug 2009
• To switch or not to switch: the effects of potassium and sodium ions on alpha-poly-L-glutamate conformations in aqueous solutions. 10 Aug 2009
• The equivalent of a thallium binding residue from an archeal homolog controls cation interactions in brain glutamate transporters. 9 Aug 2009
• Interferon-gamma suppresses Na+ -H+ exchanger in cultured human endolymphatic sac epithelial cells. 30 Jul 2009
• Modulation of Kir4.1 and Kir4.1-Kir5.1 channels by extracellular cations. 14 Jul 2009
• Effect of Na, Ca and pH on simultaneous uptake of Cd, Cu, Ni, Pb, and Zn in the water flea Daphnia magna measured using stable isotopes. 4 Jun 2009
• Postexercise rehydration in man: the effects of osmolality and carbohydrate content of ingested drinks. 29 May 2009
• Intestinal physiology and peptidase activity in male pigs are modulated by consumption of corn culture extracts containing fumonisins. 25 May 2009
• Specific expression and regulation of glucose transporters in zebrafish ionocytes. 18 May 2009
• An atypical PMR2 locus is responsible for hypersensitivity to sodium and lithium cations in the laboratory strain Saccharomyces cerevisiae CEN.PK113-7D. 12 May 2009
• Na(+) but not Cl(-) or osmotic stress is involved in NaCl-induced expression of Glutathione reductase in roots of rice seedlings. 5 May 2009
• HDAC2 negatively regulates memory formation and synaptic plasticity. 5 May 2009
• Electrophysiological effects of orexin/hypocretin on nucleus accumbens shell neurons in rats: an in vitro study. 2 May 2009
• Subinhibitory concentrations of fluconazole increase the intracellular sodium content in both fluconazole-resistant and -sensitive Candida albicans strains. 29 Apr 2009
• Characterization of the putative tryptophan synthase beta-subunit from Mycobacterium tuberculosis. 29 Apr 2009
• [Effects of seed priming on drought tolerence in Prunella vulgaris] 29 Apr 2009
• The drug of abuse gamma-hydroxybutyrate is a substrate for sodium-coupled monocarboxylate transporter (SMCT) 1 (SLC5A8): characterization of SMCT-mediated uptake and inhibition. 21 Apr 2009
• Conserved glutamate residues Glu-343 and Glu-519 provide mechanistic insights into cation/nucleoside cotransport by human concentrative nucleoside transporter hCNT3. 18 Apr 2009
• Identification of conformationally sensitive amino acids in the Na(+)/dicarboxylate symporter (SdcS). 5 Apr 2009
• Fluorescent sensor for monitoring structural changes of G-quadruplexes and detection of potassium ion. 30 Mar 2009

See a longer list of these articles.

Technical information about 'Sodium'

Definition: An element that is a member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23. With a valence of 1, it has a strong affinity for oxygen and other nonmetallic elements. Sodium provides the chief cation of the extracellular body fluids. Its salts are the most widely used in medicine. (From Dorland, 27th ed) Physiologically the sodium ion plays a major role in blood pressure regulation, maintenance of fluid volume, and electrolyte balance.

Chemical name: Sodium

Registry Number: 7440-23-5

Descriptor UI: D012964

Alternative terms: Sodium; Sodium Ion Level; Ion Level, Sodium; Level, Sodium Ion;

Related Mesh Headings: Hypernatremia; Hyponatremia; Natriuresis; Sodium Isotopes; Sodium Radioisotopes;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; classification; deficiency; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D01.268.549.750; D01.552.528.850;

Technical Notes: an alkali metal; Na-23; /physiol permitted; /blood: note also HYPERNATREMIA & HYPONATREMIA; /defic: consider also HYPONATREMIA; /metab: consider also SODIUM CHANNELS & SODIUM-POTASSIUM PUMP; /urine: consider also NATRIURESIS; SODIUM, DIETARY is also available