Sodium Channels - Metabolism
Research News and Information

Sunday, November 22, 2009

Developmental switch of the expression of ion channels in human dendritic cells.

9 Sep 2009 Modulation of the expression and activity of plasma membrane ion channels is one of the mechanisms by which immune cells can regulate their intracellular Ca(2+) signaling pathways required for proliferation and/or differentiation. Voltage-gated K+ ... Read more...

Energy-efficient action potentials in hippocampal mossy fibers.

9 Sep 2009 Action potentials in nonmyelinated axons are considered to contribute substantially to activity-dependent brain metabolism. Here we show that fast Na+ current decay and delayed K+ current onset during action potentials in nonmyelinated mossy fibers ... Read more...

Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors.

Sep 2009 Regulation of sodium flux across the cell membrane plays a vital role in the generation of action potentials and regulation of membrane excitability in cells such as cardiomyocytes and neurons. Alteration of sodium channel function has been ... Read more...

Latest indexed articles for 'Sodium Channels - Metabolism'

These are the very latest articles for this heading:

• Developmental switch of the expression of ion channels in human dendritic cells. 9 Sep 2009
• Energy-efficient action potentials in hippocampal mossy fibers. 9 Sep 2009
• Neuroscience. Low-cost travel in neurons. 9 Sep 2009
• Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors. Sep 2009
• The genetic basis of Brugada syndrome: a mutation update. 30 Aug 2009
• A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain. 30 Aug 2009
• Protection of neurons derived from human neural progenitor cells by veratridine. 24 Aug 2009
• A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes. 19 Aug 2009
• Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit. 17 Aug 2009
• Effects of scorpion toxin on excitatory and inhibitory presynaptic terminals. 13 Aug 2009
• In vitro analysis of glial cell function in ganglioside-deficient mice. 13 Aug 2009
• Identification and functional characterization of the promoter of the mouse sodium-activated sodium channel Na(x) gene (Scn7a). 13 Aug 2009
• Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles. 11 Aug 2009
• Regulated and aberrant glycosylation modulate cardiac electrical signaling. 5 Aug 2009
• GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A. 5 Aug 2009
• Loss of plakophilin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. 4 Aug 2009
• Using lidocaine and benzocaine to link sodium channel molecular conformations to state-dependent antiarrhythmic drug affinity. 4 Aug 2009
• Identification of protein domains that control proton and calcium sensitivity of ASIC1a. 2 Aug 2009
• The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na(+) channel. 30 Jul 2009
• Developments in autonomic research: a review of the latest literature. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Sodium Channels'

Definition: Cell membrane glycoproteins selective for sodium ions. Fast sodium current is associated with the action potential in neural membranes.

Registry Number: 0

Descriptor UI: D015222

Alternative terms: Sodium Channels; Channels, Sodium; Sodium Ion Channels; Channels, Sodium Ion; Sodium Channel; Channel, Sodium; Ion Channel, Sodium; Channel, Sodium Ion; Sodium Ion Channel; Ion Channels, Sodium;

Related Mesh Headings: Sodium-Potassium-Exchanging ATPase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.530.400.875; D12.776.543.550.425.875; D12.776.543.585.400.875;

History Note: 89

Technical Notes: /biosyn /drug eff /physiol /rad eff /ultrastruct permitted; DF: NA CHANNELS