Sodium Channels
Research News and Information

Sunday, November 22, 2009

T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids.

19 Oct 2009 Lipoamino acids are anandamide-related endogenous molecules that induce analgesia via unresolved mechanisms. Here, we provide evidence that the T-type/Cav3 calcium channels are important pharmacological targets underlying their physiological ... Read more...

Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity.

12 Oct 2009 Inhibitor kappaB kinase (IKK) regulates the activity of the transcription factor nuclear factor-kappa B that normally protects neurons against excitotoxicity. Constitutively active IKK is enriched at axon initial segments and nodes of Ranvier (NR). ... Read more...

De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies.

27 Sep 2009 BACKGROUND: Mutations of voltage-gated sodium channel alpha(II) gene, SCN2A, have been described in a wide spectrum of epilepsies. While inherited SCN2A mutations have been identified in multiple mild epilepsy cases, a de novo SCN2A-R102X mutation, ... Read more...

Latest indexed articles for 'Sodium Channels'

These are the very latest articles for this heading:

• T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. 19 Oct 2009
• Inhibitor kappaB Kinase beta deficiency in primary nociceptive neurons increases TRP channel sensitivity. 12 Oct 2009
• De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. 27 Sep 2009
• Child Neurology: Dravet syndrome: when to suspect the diagnosis. 27 Sep 2009
• Missense mutation of the sodium channel gene SCN2A causes Dravet syndrome. 21 Sep 2009
• A critical period for activity-dependent synaptic development during olfactory bulb adult neurogenesis. 21 Sep 2009
• A patient with episodic ataxia and paramyotonia congenita due to mutations in KCNA1 and SCN4A. 20 Sep 2009
• Developmental switch of the expression of ion channels in human dendritic cells. 9 Sep 2009
• Energy-efficient action potentials in hippocampal mossy fibers. 9 Sep 2009
• Neuroscience. Low-cost travel in neurons. 9 Sep 2009
• Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium. 7 Sep 2009
• Liability of the voltage-gated sodium channel gene SCN2A R19K polymorphism to oxaliplatin-induced peripheral neuropathy. 5 Sep 2009
• Visualizing sodium dynamics in isolated cardiomyocytes using fluorescent nanosensors. Sep 2009
• The genetic basis of Brugada syndrome: a mutation update. 30 Aug 2009
• A nonsense SCN5A mutation associated with Brugada-type electrocardiogram and intraventricular conduction defects. 30 Aug 2009
• First record of a new member of Anopheles Hyrcanus Group from Iran: molecular identification, diagnosis, phylogeny, status of kdr resistance and Plasmodium infection. 30 Aug 2009
• Isoflurane inhibits the tetrodotoxin-resistant voltage-gated sodium channel Nav1.8. 30 Aug 2009
• Dravet syndrome: from electroclinical characteristics to molecular biology. 30 Aug 2009
• A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain. 30 Aug 2009
• Protection of neurons derived from human neural progenitor cells by veratridine. 24 Aug 2009

See a longer list of these articles.

Technical information about 'Sodium Channels'

Definition: Cell membrane glycoproteins selective for sodium ions. Fast sodium current is associated with the action potential in neural membranes.

Registry Number: 0

Descriptor UI: D015222

Alternative terms: Sodium Channels; Channels, Sodium; Sodium Ion Channels; Channels, Sodium Ion; Sodium Channel; Channel, Sodium; Ion Channel, Sodium; Channel, Sodium Ion; Sodium Ion Channel; Ion Channels, Sodium;

Related Mesh Headings: Sodium-Potassium-Exchanging ATPase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.157.530.400.875; D12.776.543.550.425.875; D12.776.543.585.400.875;

History Note: 89

Technical Notes: /biosyn /drug eff /physiol /rad eff /ultrastruct permitted; DF: NA CHANNELS