Sodium Oxybate - Therapeutic use
Research News and Information

Sunday, November 22, 2009

Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate.

29 Jun 2009 This study was performed to evaluate the actions of baclofen and sodium oxybate, two medications with gamma-aminobutyric acid type B (GABA(B)) receptor agonist properties, on symptoms of narcolepsy in drug-naïve teenagers. Twenty-six narcoleptic ... Read more...

Treatment of narcolepsy.

30 May 2009 Narcolepsy is a neurological disorder characterized, in its classical form, by excessive daytime sleepiness (EDS) with irresistible episodes of sleep, cataplexy, disrupted nocturnal sleep, hypnagogic/hypnopompic hallucinations and sleep paralysis. ... Read more...

Successful treatment of REM sleep behavior disorder with sodium oxybate.

29 Apr 2009 OBJECTIVES: To identify the effectiveness of sodium oxybate in treating the rapid eye movement sleep behavior disorder (RBD). METHODS: Report of effectiveness of sodium oxybate in a patient with severe RBD who was unresponsive to all other standard ... Read more...

Latest indexed articles for 'Sodium Oxybate - Therapeutic use'

These are the very latest articles for this heading:

• Questioning the likelihood that sodium oxybate can be used to successfully treat fibromyalgia: comment on the article by Russell et al. 30 Aug 2009
• Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. 29 Jun 2009
• Treatment of narcolepsy. 30 May 2009
• Successful treatment of REM sleep behavior disorder with sodium oxybate. 29 Apr 2009
• Narcolepsy--master of disguise: evidence-based recommendations for management. 29 Apr 2009
• A patient with intractable posthypoxic myoclonus (Lance-Adams syndrome) treated with sodium oxybate. 27 Feb 2009
• Precipitating pharmakologies and capital entrapments: narcolepsy and the strange cases of Provigil and Xyrem. 30 Dec 2008
• [Integrated treatment of the symptoms of narcolepsy-cataplexy syndrome with sodium oxybate] 30 Dec 2008
• Narcolepsy: a brain structural abnormality and more of interest to the anaesthetist! 30 Dec 2008
• Weight loss in narcolepsy patients treated with sodium oxybate. 15 Nov 2008
• What constitutes a normal ante-mortem urine GHB concentration? 27 Oct 2008
• Behavioral analyses of GHB: receptor mechanisms. 27 Oct 2008
• Exacerbation of cataplexy following gradual withdrawal of antidepressants: manifestation of probable protracted rebound cataplexy. 24 Aug 2008
• Management of narcolepsy. 29 Jun 2008
• Pediatric narcolepsy. 26 Mar 2008
• Sodium oxybate: efficacy, safety and tolerability in the treatment of narcolepsy with or without cataplexy. 28 Feb 2008
• Treatment of narcolepsy and other hypersomnias of central origin. 29 Nov 2007
• Gamma hydroxy butyric acid and sodium oxybate used to treat posttraumatic stress disorder. 29 Nov 2007
• Stay awake! Understanding, diagnosing, and successfully managing narcolepsy. 30 Oct 2007
• Treatment of drop attacks in Coffin-Lowry syndrome with the use of sodium oxybate. 30 Oct 2007

See a longer list of these articles.

Technical information about 'Sodium Oxybate'

Definition: The sodium salt of 4-hydroxybutyric acid. Anesthetic used for both induction and maintenance. It may cause bradycardia and dyskinesias.

Chemical name: Butanoic acid, 4-hydroxy-, monosodium salt

Registry Number: 502-85-2

Descriptor UI: D012978

Alternative terms: Sodium Oxybate; Oxybate, Sodium; Sodium Oxybutyrate; Oxybutyrate, Sodium; Sodium gamma-Hydroxybutyrate; Sodium gamma Hydroxybutyrate; 4-Hydroxybutyrate Sodium; 4 Hydroxybutyrate Sodium; Oxybate Sodium; Gamma-OH; Gamma OH; SERB Brand of Sodium Oxybate; Xyrem; Orphan Brand of Sodium Oxybate; gamma-Hydroxybutyrate; gamma Hydroxybutyrate; Somsanit; Köhler Brand of Sodium Oxybate;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Adjuvants, Anesthesia; Anesthetics, Intravenous;

Tree Number: D02.241.081.160.400.410.700; D02.241.511.400.410.700;

History Note: 91(75); was see under HYDROXYBUTYRATES 1975-90