Somatostatin - Metabolism
Research News and Information

Monday, March 22, 2010

Mapping of the ligand-binding site on the b' domain of human PDI: interaction with peptide ligands and the x-linker region.

23 Sep 2009 PDI (protein disulfide-isomerase) catalyses the formation of native disulfide bonds of secretory proteins in the endoplasmic reticulum. PDI consists of four thioredoxin-like domains, of which two contain redox-active catalytic sites (a and a'), and ... Read more...

Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin.

10 Aug 2009 AIMS: Extracellular ATP modulates pulsatile release of insulin, glucagon and somatostatin by activating P2Y(1) receptors. The present study examines if adenosine via A(1) receptors (A(1)R) interferes with pulsatile islet hormone release. MAIN ... Read more...

Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation.

30 Jul 2009 Several different populations of interneurons in the murine cortex, including somatostatin (SST)- or parvalbumin (PV)-expressing cells, are born in the ventral ganglionic eminences during mid-gestation and then migrate tangentially to the cortex. ... Read more...

Latest indexed articles for 'Somatostatin - Metabolism'

These are the very latest articles for this heading:

• Mapping of the ligand-binding site on the b' domain of human PDI: interaction with peptide ligands and the x-linker region. 23 Sep 2009
• Absence of adenosine A1 receptors unmasks pulses of insulin release and prolongs those of glucagon and somatostatin. 10 Aug 2009
• Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiation. 30 Jul 2009
• Neuronostatin inhibits cardiac contractile function via a protein kinase A- and JNK-dependent mechanism in murine hearts. 22 Jun 2009
• Induced in vitro differentiation of pancreatic-like cells from human amnion-derived fibroblast-like cells. 21 Jun 2009
• Inhibitory inputs to hippocampal interneurons are reorganized in Lis1 mutant mice. 8 Jun 2009
• Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1. 6 Jun 2009
• Regulation of basal, pulsatile, and entropic (patterned) modes of GH secretion in a putatively low-somatostatin milieu in women. 31 May 2009
• [Influence of electroacupuncture on hippocampal somatostatin (SS) and SS mRNA expression in chronic stress-induced depression rats] 30 May 2009
• Somatostatin modulates mast cell-induced responses in murine spinal neurons and satellite cells. 26 May 2009
• Expression of somatostatin and somatostatin receptor subtypes in Apolipoprotein D (ApoD) knockout mouse brain: An immunohistochemical analysis. 20 May 2009
• Predictive value of 18F-FDG PET and somatostatin receptor scintigraphy in patients with metastatic endocrine tumors. 12 May 2009
• Interactions of ghrelin signaling pathways with the GH neuroendocrine axis: a new and experimentally tested model. 9 May 2009
• Effects of the antipsychotic drug haloperidol on the somastostatinergic system in SH-SY5Y neuroblastoma cells. 9 May 2009
• Parathyroid hormone 2 receptor and its endogenous ligand tuberoinfundibular peptide of 39 residues are concentrated in endocrine, viscerosensory and auditory brain regions in macaque and human. May 2009
• Combinations of growth factors enhance the potency of islets in vitro. 29 Apr 2009
• Regulation of colonic apical potassium (BK) channels by cAMP and somatostatin. 28 Apr 2009
• Nesidioblastosis as a cause of focal pancreatic 111In-pentetreotide uptake in a patient with putative VIPoma: another differential diagnosis. 20 Apr 2009
• alpha-Tocopherol decreases the somatostatin receptor-effector system and increases the cyclic AMP/cyclic AMP response element binding protein pathway in the rat dentate gyrus. 20 Apr 2009
• The mesopontine rostromedial tegmental nucleus: A structure targeted by the lateral habenula that projects to the ventral tegmental area of Tsai and substantia nigra compacta. 18 Apr 2009

See a longer list of these articles.

Technical information about 'Somatostatin'

Definition: A 14-amino acid peptide named for its ability to inhibit pituitary GROWTH HORMONE release, also called somatotropin release-inhibiting factor. It is expressed in the central and peripheral nervous systems, the gut, and other organs. SRIF can also inhibit the release of THYROID-STIMULATING HORMONE; PROLACTIN; INSULIN; and GLUCAGON besides acting as a neurotransmitter and neuromodulator. In a number of species including humans, there is an additional form of somatostatin, SRIF-28 with a 14-amino acid extension at the N-terminal.

Registry Number: 51110-01-1

Descriptor UI: D013004

Alternative terms: Somatostatin; Somatostatin, Cyclic; Somatostatin-14; Somatostatin 14; SRIH-14; Somatotropin Release-Inhibiting Factor; Somatotropin Release Inhibiting Factor; Somatotropin Release-Inhibiting Hormone; Somatotropin Release Inhibiting Hormone; Cyclic Somatostatin; Stilamin; Somatofalk;

Related Mesh Headings: Receptors, Somatostatin;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Hormones;

Tree Number: D06.472.699.327.700.875; D06.472.699.587.780; D12.644.400.400.700.875; D12.644.548.365.700.875; D12.644.548.586.780; D12.776.641.650.405.700.875;

Online Note: use SOMATOSTATIN to search SOMATOTROPIN RELEASE INHIBITING HORMONE 1975-84

History Note: 99