Spectrometry, Mass, Electrospray Ionization
Research News and Information

Saturday, November 21, 2009

Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin.

15 Nov 2009 Enhanced expression of cyclooxygenase-2 (COX-2) is associated with development of several cancers. The product of COX-2, prostaglandin H(2) (PGH(2)), can undergo spontaneous rearrangement and nonenzymatic ring cleavage to form the highly reactive ... Read more...

Modeling the syn disposition of nitrogen donors in non-heme diiron enzymes. Synthesis, characterization, and hydrogen peroxide reactivity of diiron(III) complexes with the syn N-donor ligand H2BPG2DEV.

12 Oct 2009 In order to model the syn disposition of histidine residues in carboxylate-bridged non-heme diiron enzymes, we prepared a new dinucleating ligand, H(2)BPG(2)DEV, that provides this geometric feature. The ligand incorporates biologically relevant ... Read more...

Validated LC coupled to ESI-MS/MS analysis for fentanyl in human plasma and UV analysis in applied reservoir transdermal patches using a simple and rapid procedure.

29 Sep 2009 BACKGROUND AND OBJECTIVES: Fentanyl has been used for cancer pain in transdermal formulation. The aim of the present study was to establish an analytical method for fentanyl in human plasma and in an applied transdermal reservoir patch ... Read more...

Latest indexed articles for 'Spectrometry, Mass, Electrospray Ionization'

These are the very latest articles for this heading:

• Characterization of covalent adducts of nucleosides and DNA formed by reaction with levuglandin. 15 Nov 2009
• Modeling the syn disposition of nitrogen donors in non-heme diiron enzymes. Synthesis, characterization, and hydrogen peroxide reactivity of diiron(III) complexes with the syn N-donor ligand H2BPG2DEV. 12 Oct 2009
• Validated LC coupled to ESI-MS/MS analysis for fentanyl in human plasma and UV analysis in applied reservoir transdermal patches using a simple and rapid procedure. 29 Sep 2009
• Structural characterization and identification of iridoid glycosides, saponins, phenolic acids and flavonoids in Flos Lonicerae Japonicae by a fast liquid chromatography method with diode-array detection and time-of-flight mass spectrometry. 29 Sep 2009
• Characterization of novel hydrolysis products of carbapenems by electrospray ionization mass spectrometry. 29 Sep 2009
• Comparison of collision- versus electron-induced dissociation of Pt(II) ternary complexes of histidine- and methionine-containing peptides. 29 Sep 2009
• Assigning glucose or galactose as the primary glycosidic sugar in 3-O-mono-, di- and triglycosides of kaempferol using negative ion electrospray and serial mass spectrometry. 29 Sep 2009
• Mass spectrometry of intact neutral macromolecules using intense non-resonant femtosecond laser vaporization with electrospray post-ionization. 29 Sep 2009
• A rapid screening method for prenylated flavonoids with ultra-high-performance liquid chromatography/electrospray ionisation mass spectrometry in licorice root extracts. 29 Sep 2009
• Direct olive oil analysis by low-temperature plasma (LTP) ambient ionization mass spectrometry. 29 Sep 2009
• Detection of aminothiols through surface-assisted laser desorption/ionization mass spectrometry using mixed gold nanoparticles. 29 Sep 2009
• In vivo interactions between BZP and TFMPP (party pill drugs). 23 Sep 2009
• Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. 22 Sep 2009
• Monitoring inhibitor-induced conformational population shifts in HIV-1 protease by pulsed EPR spectroscopy. 20 Sep 2009
• Arsenic metalation of seaweed Fucus vesiculosus metallothionein: the importance of the interdomain linker in metallothionein. 20 Sep 2009
• Structural and genetic basis for the serological differentiation of Pasteurella multocida Heddleston serotypes 2 and 5. 16 Sep 2009
• Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. 15 Sep 2009
• Binding of Hg2+ with phytochelatins: study by differential pulse voltammetry on rotating Au-disk electrode, electrospray ionization mass-spectrometry, and isothermal titration calorimetry. 13 Sep 2009
• Terpenylic acid and related compounds from the oxidation of alpha-pinene: implications for new particle formation and growth above forests. 13 Sep 2009
• Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry. 13 Sep 2009

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Technical information about 'Spectrometry, Mass, Electrospray Ionization'

Definition: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.

Descriptor UI: D021241

Alternative terms: Spectrometry, Mass, Electrospray Ionization; Electrospray Ionization Mass Spectrometry; ESI Mass Spectrometry; Mass Spectrometry, ESI; Spectrometry, ESI Mass;

Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;

Tree Number: E05.196.566.600;

History Note: 2001