Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - Methods
Research News and Information

Sunday, November 22, 2009

Study of human neutrophil peptides in saliva by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

29 Sep 2009 Matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry is used to rapidly characterize the human neutrophil peptides - HNP 1, 2, and 3 - in saliva. The saliva excreted from the parotid and sublingual/submandibular ... Read more...

Study of latent fingermarks by matrix-assisted laser desorption/ionisation mass spectrometry imaging of endogenous lipids.

29 Sep 2009 Identification of suspects via fingermark analysis is one of the mainstays of forensic science. The success in matching fingermarks, using conventional fingermark scanning and database searching, strongly relies on the enhancement method adopted for ... Read more...

Serum protein profiles in myasthenia gravis.

29 Sep 2009 BACKGROUND: The diagnosis of myasthenia gravis (MG) remains challenging. We performed a proteome-wide search for potential serum protein diagnostic markers for MG using surface-enhanced laser desorption/ionization (SELDI) time-of-flight mass ... Read more...

Latest indexed articles for 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - Methods'

These are the very latest articles for this heading:

• Study of human neutrophil peptides in saliva by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. 29 Sep 2009
• Study of latent fingermarks by matrix-assisted laser desorption/ionisation mass spectrometry imaging of endogenous lipids. 29 Sep 2009
• Invited commentary. 29 Sep 2009
• Serum protein profiles in myasthenia gravis. 29 Sep 2009
• High-throughput profiling of formalin-fixed paraffin-embedded tissue using parallel electrophoresis and matrix-assisted laser desorption ionization mass spectrometry. 30 Aug 2009
• Quantification of target proteins using hydrogel antibody arrays and MALDI time-of-flight mass spectrometry (A2M2S). 30 Aug 2009
• Field-free transmission geometry atmospheric pressure matrix-assisted laser desorption/ionization for rapid analysis of unadulterated tissue samples. 30 Aug 2009
• Mass spectrometric study of N-glycans from serum of woodchucks with liver cancer. 30 Aug 2009
• Evaluation of chemical degradation of a trivalent recombinant protein vaccine against botulinum neurotoxin by LysC peptide mapping and MALDI-TOF mass spectrometry. 30 Aug 2009
• MALDI-MS-NIST library approach for colorectal cancer diagnosis. 30 Aug 2009
• Positive chemical ionization (PCI)-like behavior of estradiol in matrix-assisted laser desorption/ionization. 30 Aug 2009
• Heterobifunctional isotope-labeled amine-reactive photo-cross-linker for structural investigation of proteins by matrix-assisted laser desorption/ionization tandem time-of-flight and electrospray ionization LTQ-Orbitrap mass spectrometry. 30 Aug 2009
• Analysis of human plasma lipids and soybean lecithin by means of high-performance thin-layer chromatography and matrix-assisted laser desorption/ionization mass spectrometry. 30 Aug 2009
• Mass spectrometric analysis of carbohydrates labeled with a biotinylated tag. 30 Aug 2009
• Optimal preparation methods for automated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling of low molecular weight proteins and peptides. 30 Aug 2009
• Global proteome analysis of hepatitis B virus expressing human hepatoblastoma cell line HepG2. 30 Aug 2009
• Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. 25 Aug 2009
• Conservation of the function counts: homologous neurons express sequence-related neuropeptides that originate from different genes. 25 Aug 2009
• Selective modulation of amyloid-beta peptide degradation by flurbiprofen, fenofibrate, and related compounds regulates Abeta levels. 20 Aug 2009
• NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade. 19 Aug 2009

See a longer list of these articles.

Technical information about 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization'

Definition: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.

Descriptor UI: D019032

Alternative terms: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Mass Spectrometry, Matrix-Assisted Laser Desorption-Ionization; Mass Spectrometry, Matrix Assisted Laser Desorption Ionization; Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry; Matrix Assisted Laser Desorption Ionization Mass Spectrometry; MALDI; Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization; MS-MALD; MALD-MS; MALDI-MS; MALDI MS; Laser Desorption-Ionization Mass Spectrometry, Matrix-Assisted; Laser Desorption Ionization Mass Spectrometry, Matrix Assisted; Mass Spectroscopy, Matrix-Assisted Laser Desorption-Ionization; Mass Spectroscopy, Matrix Assisted Laser Desorption Ionization; Surface Enhanced Laser Desorption Ionization Mass Spectrometry; SELDI-TOF-MS;

Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;

Tree Number: E05.196.566.755;

History Note: 96