Stevens-Johnson Syndrome - Immunology
Research News and Information

Sunday, November 22, 2009

Genetic basis for idiosyncratic reactions to antiepileptic drugs.

30 Mar 2009 PURPOSE OF REVIEW: In recent years, there has been an explosion of genetic research in epilepsy, including a search for genetic markers of adverse reactions to antiepileptic drugs. This article will focus on recent findings concerning genetic ... Read more...

Immunogenetics of drug-induced skin blistering disorders. Part I: Perspective.

30 Mar 2009 The overall immunopathogenesis relevant to a large series of disorders caused by a drug or its associated hyperimmune condition is discussed based upon the examination of the genetics of severe drug-induced bullous skin problems (sporadic ... Read more...

Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic tests.

30 Dec 2008 Nonimmediate allergic reactions (NIRs) to drugs, which are the most common reactions induced by specific immunologic mechanisms, can be induced by all commercially available drugs. NIRs can appear hours, days, or even weeks after drug intake. They ... Read more...

Latest indexed articles for 'Stevens-Johnson Syndrome - Immunology'

These are the very latest articles for this heading:

• Foreword. Drug allergy and primum non-nocere. 30 Jul 2009
• Genetic basis for idiosyncratic reactions to antiepileptic drugs. 30 Mar 2009
• Immunogenetics of drug-induced skin blistering disorders. Part I: Perspective. 30 Mar 2009
• Nonimmediate allergic reactions induced by drugs: pathogenesis and diagnostic tests. 30 Dec 2008
• Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. 29 Sep 2008
• Oxcarbazepine-induced Stevens-Johnson syndrome in a patient with HLA-B*1502 genotype. 8 Sep 2008
• Innate immunity of the ocular surface and ocular surface inflammatory disorders. 30 Aug 2008
• Increased soluble Fas ligand levels in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis preceding skin detachment. 7 Aug 2008
• Stevens-Johnson syndrome and toxic epidermal necrolysis. 7 Jul 2008
• Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-/- mice. 23 Apr 2008
• [Mycoplasma pneumoniae is not a respiratory pathogen only: two case reports of ''atypical'' clinical presentations] 30 Jan 2008
• A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. 30 Jan 2008
• Abnormal keratocytes and stromal inflammation in chronic phase of severe ocular surface diseases with stem cell deficiency. 20 Jan 2008
• Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses. 30 Dec 2007
• Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption. 29 Nov 2007
• Serum interleukin-13 levels are increased in patients with Stevens-Johnson syndrome/ toxic epidermal necrolysis but not in those with erythema multiforme. 15 Oct 2007
• Association of IL4R polymorphisms with Stevens-Johnson syndrome. 25 Sep 2007
• Human leukocyte antigens and drug hypersensitivity. 30 Jul 2007
• Immunohistochemical expression of apoptotic markers in drug-induced erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. 29 Jun 2007
• T cell populations propagating in the peripheral blood of patients with drug eruptions. 27 Jun 2007

See a longer list of these articles.

Technical information about 'Stevens-Johnson Syndrome'

Definition: A variant of bullous erythema multiforme. It ranges from mild skin and mucous membrane lesions to a severe, sometimes fatal systemic disorder. Ocular symptoms include ulcerative conjunctivitis, keratitis, iritis, uveitis, and sometimes blindness. The cause of the disease is unknown.

Descriptor UI: D013262

Alternative terms: Stevens-Johnson Syndrome; Stevens Johnson Syndrome;

Allowable Qualifiers: embryology; enzymology; ethnology; etiology; genetics; history; immunology; metabolism; microbiology; mortality; nursing; epidemiology; parasitology; pathology; physiopathology; prevention & control; psychology; radiography; radionuclide imaging; radiotherapy; rehabilitation; surgery; therapy; urine; veterinary; ultrasonography; virology; blood; cerebrospinal fluid; chemically induced; classification; complications; congenital; diagnosis; diet therapy; drug therapy; economics;

Tree Number: C07.465.864.500; C17.800.229.400.683; C17.800.865.475.683;

Technical Notes: a sometimes fatal form of erythema multiforme