Substance P - Metabolism
Research News and Information

Sunday, November 22, 2009

Deficits in substance P mRNA levels in the CeA are inversely associated with alcohol-motivated responding.

30 Oct 2009 In the present study, in vitro and in vivo studies were conducted to determine the relationship between innate substance P (SP) levels and alcohol-motivated behavior in alcohol-preferring (P) and nonpreferring (NP) rat lines. In Experiment 1, in ... Read more...

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia.

30 Aug 2009 During dietary deficiency of magnesium neurogenic inflammation is mediated, primarily, by elevated levels of substance P (SP). The enzyme most specific for degrading this neuropeptide is neutral endopeptidase (NEP). In recent studies we found that ... Read more...

Latest indexed articles for 'Substance P - Metabolism'

These are the very latest articles for this heading:

• Deficits in substance P mRNA levels in the CeA are inversely associated with alcohol-motivated responding. 30 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia. 30 Aug 2009
• Up-regulation of the tight-junction protein ZO-1 by substance P and IGF-1 in A431 cells. 30 Jul 2009
• Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. 7 Jul 2009
• Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke. 4 Jul 2009
• Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema. 29 Jun 2009
• Modulation of the substance P release from cultured rat primary afferent neurons by zinc ions. 29 Jun 2009
• Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting. 29 Jun 2009
• Distribution of vasoactive intestinal peptide and substance P messenger ribonucleic acid in intestinal nerve of Remak of chicken. 29 Jun 2009
• An engineered substance P variant for receptor-mediated delivery of synthetic antibodies into tumor cells. 20 Jun 2009
• Visual efference neuromodulates retinal timing: in vivo roles of octopamine, substance P, circadian phase, and efferent activation in Limulus. 15 Jun 2009
• NK1 receptor-mediated endothelium-dependent relaxation and contraction with different sensitivity to post-receptor signaling in pulmonary arteries. 14 Jun 2009
• Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. 10 Jun 2009
• Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments. 7 Jun 2009
• Intraluminal blockade of cell-surface CD74 and glucose regulated protein 78 prevents substance P-induced bladder inflammatory changes in the rat. 6 Jun 2009
• Developmental changes in the mRNA expression of neuropeptides and dopamine and glutamate receptors in neonates and adult rats after ventral hippocampal lesion. 2 Jun 2009
• Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon. 2 Jun 2009
• Presynaptic modulation of tonic and respiratory inputs to cardiovagal motoneurons by substance P. Jun 2009
• A role for the substance P/NK-1 receptor complex in cell proliferation in oral squamous cell carcinoma. 30 May 2009

See a longer list of these articles.

Technical information about 'Substance P'

Definition: An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

Registry Number: 33507-63-0

Descriptor UI: D013373

Alternative terms: Substance P; P, Substance; Euler-Gaddum Substance P; Euler Gaddum Substance P; P, Euler-Gaddum Substance; Substance P, Euler-Gaddum; SP(1-11); Hypothalamic Substance P; P, Hypothalamic Substance; Substance P, Hypothalamic;

Related Mesh Headings: Receptors, Neurokinin-1;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Neurotransmitter Agents;

Tree Number: D12.644.276.812.900.866; D12.644.400.800.750; D12.644.456.800.866; D12.776.467.812.900.866; D12.776.641.650.800.750; D23.469.050.375.850.890; D23.529.812.900.866;

Online Note: use SUBSTANCE P to search EULER-GADDUM SUBSTANCE P 1973-92 & HYPOTHALAMIC SUBSTANCE P 1977-92

History Note: 73(65); was see under PEPTIDES 1963-72; EULER-GADDUM SUBSTANCE P was see SUBSTANCE P 1973-92; HYPOTHALAMIC SUBSTANCE P was see SUBSTANCE P 1977-92