Substance P
Research News and Information

Sunday, November 22, 2009

Deficits in substance P mRNA levels in the CeA are inversely associated with alcohol-motivated responding.

30 Oct 2009 In the present study, in vitro and in vivo studies were conducted to determine the relationship between innate substance P (SP) levels and alcohol-motivated behavior in alcohol-preferring (P) and nonpreferring (NP) rat lines. In Experiment 1, in ... Read more...

Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord.

19 Oct 2009 Coactivation of spinal alpha(2)-adrenergic receptors (ARs) and opioid receptors produces antinociceptive synergy. Antinociceptive synergy between intrathecally administered alpha(2)AR and opioid agonists is well documented, but the mechanism ... Read more...

Antimicrobial properties of hemokinin-1 against strains of Pseudomonas aeruginosa.

30 Sep 2009 AIMS: In this study, we examined whether hemokinin-1, the newest member of the tachykinin family and a close relative of substance P, has antimicrobial properties which have been attributed to other neuropeptides including substance P. MAIN METHODS: ... Read more...

Latest indexed articles for 'Substance P'

These are the very latest articles for this heading:

• Deficits in substance P mRNA levels in the CeA are inversely associated with alcohol-motivated responding. 30 Oct 2009
• Protein kinase C mediates the synergistic interaction between agonists acting at alpha2-adrenergic and delta-opioid receptors in spinal cord. 19 Oct 2009
• Antimicrobial properties of hemokinin-1 against strains of Pseudomonas aeruginosa. 30 Sep 2009
• Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist. 29 Sep 2009
• Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor. 13 Sep 2009
• Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia. 30 Aug 2009
• Electron-capture dissociation (ECD), collision-induced dissociation (CID) and ECD/CID in a linear radio-frequency-free magnetic cell. 30 Aug 2009
• The neurokinin-1 receptor modulates the methamphetamine-induced striatal apoptosis and nitric oxide formation in mice. 11 Aug 2009
• Metastable atom-activated dissociation mass spectrometry: leucine/isoleucine differentiation and ring cleavage of proline residues. 30 Jul 2009
• Up-regulation of the tight-junction protein ZO-1 by substance P and IGF-1 in A431 cells. 30 Jul 2009
• Neurokinins inhibit low threshold inactivating K+ currents in capsaicin responsive DRG neurons. 21 Jul 2009
• Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. 7 Jul 2009
• Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide. 5 Jul 2009
• Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke. 4 Jul 2009
• Endocannabinoids mediate tachykinin-induced effects in the lamprey locomotor network. 29 Jun 2009
• Alteration of neuropeptides in the lung tissue correlates brain death-induced neurogenic edema. 29 Jun 2009
• Modulation of the substance P release from cultured rat primary afferent neurons by zinc ions. 29 Jun 2009
• Advances in treatment for neurotrophic keratopathy. 29 Jun 2009
• Evidence for a re-evaluation of the neurochemical and anatomical bases of chemotherapy-induced vomiting. 29 Jun 2009
• Concordance between substance P levels and antiemetic guidelines. 29 Jun 2009

See a longer list of these articles.

Technical information about 'Substance P'

Definition: An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of PAIN, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.

Registry Number: 33507-63-0

Descriptor UI: D013373

Alternative terms: Substance P; P, Substance; Euler-Gaddum Substance P; Euler Gaddum Substance P; P, Euler-Gaddum Substance; Substance P, Euler-Gaddum; SP(1-11); Hypothalamic Substance P; P, Hypothalamic Substance; Substance P, Hypothalamic;

Related Mesh Headings: Receptors, Neurokinin-1;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Pharmacological Action: Neurotransmitter Agents;

Tree Number: D12.644.276.812.900.866; D12.644.400.800.750; D12.644.456.800.866; D12.776.467.812.900.866; D12.776.641.650.800.750; D23.469.050.375.850.890; D23.529.812.900.866;

Online Note: use SUBSTANCE P to search EULER-GADDUM SUBSTANCE P 1973-92 & HYPOTHALAMIC SUBSTANCE P 1977-92

History Note: 73(65); was see under PEPTIDES 1963-72; EULER-GADDUM SUBSTANCE P was see SUBSTANCE P 1973-92; HYPOTHALAMIC SUBSTANCE P was see SUBSTANCE P 1977-92