Substantia Nigra
Research News and Information

Sunday, November 22, 2009

Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway.

5 Oct 2009 These electrophysiological experiments, in slices and intact animals, study the effects of in vivo chronic exposure to nicotine on functional alpha4beta2* nAChRs in the nigrostriatal dopaminergic (DA) pathway. Recordings were made in wild-type and ... Read more...

Dopamine D2 receptor knockout mice develop features of Parkinson disease.

29 Sep 2009 OBJECTIVE: This study questions whether increased dopamine (DA) turnover in nigral neurons leads to formation of Lewy bodies (LBs), the characteristic alpha-synuclein-containing cytoplasmic inclusion of Parkinson disease (PD). METHODS: Mice with ... Read more...

Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus.

29 Sep 2009 OBJECT: The aim of the current study was to examine and compare the aftereffects of local high-frequency microstimulation through the recording electrode on the firing of neurons in the subthalamic nucleus (STN) and the substantia nigra pars ... Read more...

Latest indexed articles for 'Substantia Nigra'

These are the very latest articles for this heading:

• Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway. 5 Oct 2009
• Dopamine D2 receptor knockout mice develop features of Parkinson disease. 29 Sep 2009
• Microstimulation-induced inhibition as a tool to aid targeting the ventral border of the subthalamic nucleus. 29 Sep 2009
• Neuroprotective effect of L-dopa on dopaminergic neurons is comparable to pramipexol in MPTP-treated animal model of Parkinson's disease: a direct comparison study. 14 Sep 2009
• Robust pacemaking in substantia nigra dopaminergic neurons. 31 Aug 2009
• Homocysteine-induced endoplasmic reticulum protein (herp) is up-regulated in parkinsonian substantia nigra and present in the core of Lewy bodies. 30 Aug 2009
• Acute and chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administrations elicit similar microglial activation in the substantia nigra of monkeys. 30 Aug 2009
• Effects of early vs. late initiation of levodopa treatment in hemiparkinsonian rats. 25 Aug 2009
• The substantia nigra pars compacta of the Göttingen minipig: an anatomical and stereological study. 23 Aug 2009
• Neocortical movement representations are reduced and reorganized following bilateral intrastriatal 6-hydroxydopamine infusion and dopamine type-2 receptor antagonism. 20 Aug 2009
• Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. 17 Aug 2009
• Methylation status and neurodegenerative markers in Parkinson disease. 11 Aug 2009
• NeuN is not a reliable marker of dopamine neurons in rat substantia nigra. 10 Aug 2009
• Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain. 8 Aug 2009
• Parkinsonism in hiv-infected patients on highly active antiretroviral therapy. 2 Aug 2009
• Increased Fos expression among midbrain dopaminergic cell groups during birdsong tutoring. Aug 2009
• Diffusion tensor imaging in a rat model of Parkinson's disease after lesioning of the nigrostriatal tract. 30 Jul 2009
• Medical treatment of Parkinson disease. 30 Jul 2009
• The epileptic hypothesis: developmentally related arguments based on animal models. 30 Jul 2009
• NMDA receptors mediate an early up-regulation of brain-derived neurotrophic factor expression in substantia nigra in a rat model of presymptomatic Parkinson's disease. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Substantia Nigra'

Definition: The black substance in the ventral midbrain or the nucleus of cells containing the black substance. These cells produce DOPAMINE, an important neurotransmitter in regulation of the sensorimotor system and mood. The dark colored MELANIN is a by-product of dopamine synthesis.

Descriptor UI: D013378

Alternative terms: Substantia Nigra; Nigra, Substantia; Nigras, Substantia; Substantia Nigras;

Allowable Qualifiers: abnormalities; anatomy & histology; blood supply; cytology; drug effects; embryology; enzymology; growth & development; immunology; injuries; metabolism; microbiology; parasitology; pathology; physiology; physiopathology; radiation effects; radiography; radionuclide imaging; secretion; surgery; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A08.186.211.132.659.822.731; A08.186.211.653.822.731;