Sulfonamides - Pharmacology
Research News and Information

Monday, November 23, 2009

Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling.

19 Oct 2009 Prostaglandin E(2) (PGE(2)) mediates the masculinization of adult sex behavior in rats in response to the surge in serum testosterone at approximately birth. Measures of behavioral masculinization correlate with a twofold increase in spinophilin ... Read more...

Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.

6 Oct 2009 Nonsteroidal anti-inflammatory drugs (NSAIDs) represent one of the most prescribed medications, although the chronic use of such pharmacological agents is commonly associated with numerous side effects. The demonstration that the use of COX-2 ... Read more...

Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes.

6 Oct 2009 Type 2 diabetes is a polygenic disease which afflicts nearly 200 million people worldwide and is expected to increase to near epidemic levels over the next 10-15 years. Glucokinase (GK) activators are currently under investigation by a number of ... Read more...

Latest indexed articles for 'Sulfonamides - Pharmacology'

These are the very latest articles for this heading:

• Prostaglandin E2-induced masculinization of brain and behavior requires protein kinase A, AMPA/kainate, and metabotropic glutamate receptor signaling. 19 Oct 2009
• Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors. 6 Oct 2009
• Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. 6 Oct 2009
• Identification of novel indanylsulfonamide guanylhydrazones as potent 5-HT6 serotonin receptor antagonists. 6 Oct 2009
• Differential effects of non-steroidal anti-inflammatory drugs on mitochondrial dysfunction during oxidative stress. 29 Sep 2009
• Regulation of peroxisome proliferator-activated receptor-beta/delta by the APC/beta-CATENIN pathway and nonsteroidal antiinflammatory drugs. 29 Sep 2009
• T cell receptor signaling induced by an analog peptide of type II collagen requires activation of Syk. 29 Sep 2009
• Crystallographic analysis of bacterial signal peptidase in ternary complex with arylomycin A2 and a beta-sultam inhibitor. 27 Sep 2009
• Design and evaluation of novel biphenyl sulfonamide derivatives with potent histamine H(3) receptor inverse agonist activity. 22 Sep 2009
• Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress. 16 Sep 2009
• Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). 11 Sep 2009
• Serotonin targets inhibitory synapses to induce modulation of network functions. 10 Sep 2009
• Tamsulosin and ophthalmic adverse events after cataract surgery. 7 Sep 2009
• Identification and characterization of novel TRPV4 modulators. 4 Sep 2009
• Role for CaMKII inhibition in rheumatoid arthritis: effects on HIF-1-induced VEGF production by rheumatoid synovial fibroblasts. 30 Aug 2009
• Novel pathway of endothelin-1 and reactive oxygen species in coronary vasospasm with endothelial dysfunction. 30 Aug 2009
• Enhanced ex vivo expansion of human adipose tissue-derived mesenchymal stromal cells by fibroblast growth factor-2 and dexamethasone. 30 Aug 2009
• Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis. 30 Aug 2009
• Effects of chronic blockade of 5-HT(6) receptors on NMDA receptor subunits expression. 30 Aug 2009
• Cyclooxygenase-2 prevents fas-induced liver injury through up-regulation of epidermal growth factor receptor. 30 Aug 2009

See a longer list of these articles.

Technical information about 'Sulfonamides'

Definition: A group of compounds that contain the structure SO2NH2. Members of this group, also known as sulfa drugs, are derivatives of sulfanilamide, which competitively inhibit folic acid synthesis in microorganisms, and are bacteriostatic. They have been largely supplanted by more effective and less toxic antibiotics. (From Dorland, 28th ed)

Registry Number: 0

Descriptor UI: D013449

Alternative terms: Sulfonamides; Sulfonamide Mixtures; Mixtures, Sulfonamide;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; blood; cerebrospinal fluid; chemical synthesis; classification; diagnostic use; economics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; poisoning; radiation effects; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D02.065.884; D02.886.590.700;

Online Note: use SULFONAMIDES to search SULFONAMIDE MIXTURES 1966-79

History Note: SULFONAMIDE MIXTURES was heading 1963-79