Superoxide Dismutase
Research News and Information

Saturday, November 21, 2009

p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death.

29 Nov 2009 Ethanol induces neuronal cell injury and death by dysregulating several signaling events that are controlled, in part, by activation of MAPK/ERK1/2 and/or inactivation of its corresponding phosphatase, PP1. Recently, we have purified a novel protein ... Read more...

Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine.

29 Nov 2009 BACKGROUND AND AIM: Reactive oxygen species generated during reperfusion of the tissue are known to play an important role in the basic pathophysiology of ischemia/reperfusion (I/R) injury. The aim of this study was to investigate and compare the ... Read more...

Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis.

2 Nov 2009 Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease inherited in a small subset of patients. The SOD1(G93A) transgenic mouse models this subset of patients, and studies of this strain have suggested that endoplasmic reticulum (ER) ... Read more...

Latest indexed articles for 'Superoxide Dismutase'

These are the very latest articles for this heading:

• p38SJ, a novel DINGG protein protects neuronal cells from alcohol induced injury and death. 29 Nov 2009
• Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine. 29 Nov 2009
• Reticulon-4A (Nogo-A) redistributes protein disulfide isomerase to protect mice from SOD1-dependent amyotrophic lateral sclerosis. 2 Nov 2009
• Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. 30 Oct 2009
• Thermodynamic characterization of the interaction between the C-terminal domain of extracellular superoxide dismutase and heparin by isothermal titration calorimetry. 18 Oct 2009
• Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. 17 Oct 2009
• PEGylated nanoceria as radical scavenger with tunable redox chemistry. 12 Oct 2009
• Lycopene modulates nitric oxide pathways against 3-nitropropionic acid-induced neurotoxicity. 10 Oct 2009
• Selenium increases expression of HSP70 and antioxidant enzymes to lessen oxidative damage in Fincoal-type fluorosis. 29 Sep 2009
• Bone marrow-derived cells in the central nervous system of a mouse model of amyotrophic lateral sclerosis are associated with blood vessels and express CX(3)CR1. 29 Sep 2009
• Systematic structural studies of iron superoxide dismutases from human parasites and a statistical coupling analysis of metal binding specificity. 29 Sep 2009
• Effects of ginger root (Zingiber officinale) processed to different particle sizes on growth performance, antioxidant status, and serum metabolites of broiler chickens. 29 Sep 2009
• Autophagy for the avoidance of neurodegeneration. 29 Sep 2009
• Mercury-induced oxidative stress in Indian mustard (Brassica juncea L.). 29 Sep 2009
• Genotoxic and oxidative stress-inducing effects of deltamethrin in the erythrocytes of a freshwater biomarker fish species, Channa punctata Bloch. 29 Sep 2009
• Upregulation of manganese superoxide dismutase (SOD2) is a common pathway for neuroendocrine differentiation in prostate cancer cells. 29 Sep 2009
• A superoxide dismutase-human hemoglobin fusion protein showing enhanced antioxidative properties. 26 Sep 2009
• The ALS-associated mutation G93A in human copper-zinc superoxide dismutase selectively destabilizes the remote metal binding region. 20 Sep 2009
• Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism. 16 Sep 2009
• Transcriptional upregulation of mitochondrial uncoupling protein 2 protects against oxidative stress-associated neurogenic hypertension. 15 Sep 2009

See a longer list of these articles.

Technical information about 'Superoxide Dismutase'

Definition: An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.

Chemical name: Superoxide:superoxide oxidoreductase

Registry Number: EC 1.15.1.1

Descriptor UI: D013482

Alternative terms: Superoxide Dismutase; Dismutase, Superoxide; Erythrocuprein; Hemocuprein; Ag-Zn Superoxide Dismutase; Ag Zn Superoxide Dismutase; Dismutase, Ag-Zn Superoxide; Superoxide Dismutase, Ag-Zn; Cu-Zn Superoxide Dismutase; Cu Zn Superoxide Dismutase; Dismutase, Cu-Zn Superoxide; Superoxide Dismutase, Cu-Zn; Cuprozinc Superoxide Dismutase; Dismutase, Cuprozinc Superoxide; Superoxide Dismutase, Cuprozinc; Mn-Superoxide Dismutase; Dismutase, Mn-Superoxide; Mn Superoxide Dismutase; Manganese Superoxide Dismutase; Dismutase, Manganese Superoxide; Superoxide Dismutase, Manganese; Mn-SOD; Mn SOD; Cobalt Superoxide Dismutase; Dismutase, Cobalt Superoxide; Superoxide Dismutase, Cobalt; Cu-Superoxide Dismutase; Cu Superoxide Dismutase; Dismutase, Cu-Superoxide; Fe-Zn Superoxide Dismutase; Dismutase, Fe-Zn Superoxide; Fe Zn Superoxide Dismutase; Superoxide Dismutase, Fe-Zn; Iron Superoxide Dismutase; Dismutase, Iron Superoxide; Superoxide Dismutase, Iron; Fe-Superoxide Dismutase; Dismutase, Fe-Superoxide; Fe Superoxide Dismutase;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications;

Pharmacological Action: Free Radical Scavengers;

Tree Number: D08.811.682.881;

History Note: 74(73)