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Synapses - Chemistry
Research News and Information
Definition of 'Synapses'Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions. |
Saturday, November 21, 2009
WNTs tune up the neuromuscular junction.
30 Aug 2009 
Although WNTs have been long thought of as regulators of cell fate, recent studies highlight their involvement in crucial aspects of synaptic development in the nervous system. Particularly compelling are recent studies of the neuromuscular junction ... Read more...
Visualizing the live Drosophila glial-neuromuscular junction with fluorescent dyes.
11 May 2009 
Our project identified GFP labeled glial structures at the developing larval fly neuromuscular synapse. To look at development of live glial-nerve-muscle synapses, we developed a larval tissue preparation that had features of live intact larvae, but ... Read more...
3 May 2009 Otoferlin has been proposed to be the Ca(2+) sensor in hair cell exocytosis, compensating for the classical synaptic fusion proteins synaptotagmin-1 and synaptotagmin-2. In the present study, yeast two-hybrid assays reveal myosin VI as a novel ... Read more...
Latest indexed articles for 'Synapses - Chemistry'
These are the very latest articles for this heading:
- WNTs tune up the neuromuscular junction. 30 Aug 2009
- [Extracellular matrix protein, Pikachurin, is required for photoreceptor ribbon synapse formation]
29 Jun 2009 - Visualizing the live Drosophila glial-neuromuscular junction with fluorescent dyes. 11 May 2009
- Otoferlin interacts with myosin VI: implications for maintenance of the basolateral synaptic structure of the inner hair cell. 3 May 2009
- Acetylcholine binding protein of mollusks is unlikely to act as a regulator of cholinergic neurotransmission at neurite-neurite synaptic sites in vivo. 22 Apr 2009
- Normal protein composition of synapses in Ts65Dn mice: a mouse model of Down syndrome. 20 Apr 2009
- Crystal structures of brain group-VIII phospholipase A2 in nonaged complexes with the organophosphorus nerve agents soman and sarin. 19 Apr 2009
- Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse. 12 Apr 2009
- Macromolecular connections of active zone material to docked synaptic vesicles and presynaptic membrane at neuromuscular junctions of mouse. 8 Apr 2009
- Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate. 6 Apr 2009
- Neuroscience: AMPA receptors get 'pickled'. 31 Mar 2009
- The septate junction protein caspr is required for structural support and retention of KCNQ4 at calyceal synapses of vestibular hair cells. 9 Mar 2009
- Electron microscopic localization of corticotropin-releasing factor (CRF) and CRF receptor in rat and mouse central nucleus of the amygdala. 18 Jan 2009
- Expression of synaptic and phototransduction markers during photoreceptor development in the marmoset monkey Callithrix jacchus. 8 Jan 2009
- Proteome characterization of mouse brain mitochondria using electrospray ionization tandem mass spectrometry. 30 Dec 2008
- Synaptic localization of GLT-1a in the rat somatic sensory cortex. 30 Dec 2008
- Selective reduction in synaptic proteins involved in vesicle docking and signalling at synapses in the ataxic mutant mouse stargazer. 30 Dec 2008
- Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation. 30 Oct 2008
- The role of MAP1A light chain 2 in synaptic surface retention of Cav2.2 channels in hippocampal neurons. 27 Oct 2008
- A specialized NMDA receptor function in layer 5 recurrent microcircuitry of the adult rat prefrontal cortex. 13 Oct 2008
See a longer list of these articles.
Technical information about 'Synapses'
Definition: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
Descriptor UI: D013569
Alternative terms: Synapses; Synapse;
Related Mesh Headings: Synaptic Transmission; Synaptosomes; Gap Junctions;
Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; ultrastructure; ultrasonography; chemistry; virology; genetics;
Tree Number: A08.850; A11.284.149.165.420.780;
Technical Notes: note specifics; IMMUNOLOGICAL SYNAPSES is also available; / physiol: consider also SYNAPTIC TRANSMISSION; do not confuse with SYNAPSIS see CHROMOSOME PAIRING