 |
Synapses - Metabolism
Research News and Information
Definition of 'Synapses'Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions. |
Saturday, November 21, 2009
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
27 Oct 2009 
The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, ... Read more...
12 Oct 2009 To examine the intrasynaptic arrangement of postsynaptic receptors in relation to the functional role of the synapse, we quantitatively analyzed the two-dimensional distribution of AMPA and NMDA receptors (AMPARs and NMDARs, respectively) using ... Read more...
Understanding the role of DISC1 in psychiatric disease and during normal development.
12 Oct 2009 The biology of schizophrenia is complex with multiple hypotheses (dopamine, glutamate, neurodevelopmental) well supported to underlie the disease. Pathways centered on the risk factor "disrupted in schizophrenia 1" (DISC1) may be able to explain and ... Read more...
Latest indexed articles for 'Synapses - Metabolism'
These are the very latest articles for this heading:
- ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. 27 Oct 2009
- Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses. 12 Oct 2009
- Understanding the role of DISC1 in psychiatric disease and during normal development. 12 Oct 2009
- Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. 10 Oct 2009
- Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency. 5 Oct 2009
- Molecular mechanisms that enhance synapse stability despite persistent disruption of the spectrin/ankyrin/microtubule cytoskeleton. 3 Oct 2009
- Ultrastructural analysis of local collaterals of rat ventral tegmental area neurons: GABA phenotype and synapses onto dopamine and GABA cells. 29 Sep 2009
- Autophagy promotes synapse development in Drosophila. 26 Sep 2009
- High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. 22 Sep 2009
- Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. 16 Sep 2009
- Dopamine modulation of the in vivo acetylcholine response in the Drosophila mushroom body. 13 Sep 2009
- Expression of cadherin 23 isoforms is not conserved: implications for a mouse model of Usher syndrome type 1D. 10 Sep 2009
- Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors. 7 Sep 2009
- GABAergic interneurons targeting dendrites of pyramidal cells in the CA1 area of the hippocampus. 2 Sep 2009
- Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation. Sep 2009
- Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis. 31 Aug 2009
- BDNF and NT-3 increase excitatory input connectivity in rat hippocampal cultures. 30 Aug 2009
- What drives cell morphogenesis: a look inside the vertebrate photoreceptor. 30 Aug 2009
- Serotonergic-postsynaptic receptors modulate gripping-induced immobility episodes in male taiep rats. 30 Aug 2009
- Efferent innervation to the auditory basilar papilla of scincid lizards. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Synapses'
Definition: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
Descriptor UI: D013569
Alternative terms: Synapses; Synapse;
Related Mesh Headings: Synaptic Transmission; Synaptosomes; Gap Junctions;
Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; ultrastructure; ultrasonography; chemistry; virology; genetics;
Tree Number: A08.850; A11.284.149.165.420.780;
Technical Notes: note specifics; IMMUNOLOGICAL SYNAPSES is also available; / physiol: consider also SYNAPTIC TRANSMISSION; do not confuse with SYNAPSIS see CHROMOSOME PAIRING