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Synapses - Physiopathology
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Definition of 'Synapses'

Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.

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Sunday, November 22, 2009

Tyrosine hydroxylase activity in sympathetic nervous system of rats with streptozocin-induced diabetes.

30 Jul 1989 The activity of tyrosine hydroxylase (TOH), the rate-limiting enzyme in norepinephrine biosynthesis, was measured in selected sympathetic ganglia to develop a quantitative measure of sympathetic autonomic neuropathy in streptozocin-induced diabetic ... Read more...


[Study of the mechanisms of the development of epileptic activity in neuronal networks using a simulation model]

30 Aug 1988 The occurrence of synchronous, self-sustaining seizure activity is one of the basic mechanisms underlying epileptic attacks. Using a mathematical model of neuronal network in various simulation experiments carried out in digital computer the ... Read more...


Auditory brain-stem (ABP) and somatosensory evoked potentials (SEP) in an animal model of a synaptic lesion: elevated plasma barbiturate levels.

30 Aug 1988 Experiments were conducted to determine whether a consistent pattern of auditory nerve brain-stem evoked synaptic lesion model in cats (elevated levels of the lesion model in cats (elevated levels of the barbiturate thiopental). The ABP in response ... Read more...

 

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Technical information about 'Synapses'

Definition: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.

Descriptor UI: D013569

Alternative terms: Synapses; Synapse;

Related Mesh Headings: Synaptic Transmission; Synaptosomes; Gap Junctions;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; ultrastructure; ultrasonography; chemistry; virology; genetics;

Tree Number: A08.850; A11.284.149.165.420.780;

Technical Notes: note specifics; IMMUNOLOGICAL SYNAPSES is also available; / physiol: consider also SYNAPTIC TRANSMISSION; do not confuse with SYNAPSIS see CHROMOSOME PAIRING

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