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Synapses - Ultrastructure
Research News and Information
Definition of 'Synapses'Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions. |
Sunday, November 22, 2009
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
27 Oct 2009 
The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, ... Read more...
12 Oct 2009 To examine the intrasynaptic arrangement of postsynaptic receptors in relation to the functional role of the synapse, we quantitatively analyzed the two-dimensional distribution of AMPA and NMDA receptors (AMPARs and NMDARs, respectively) using ... Read more...
29 Sep 2009 The connection between the dorsal lateral geniculate nucleus (dLGN) and area 17 of the cat is a classical model for studying thalamocortical relations. We investigated the proportion of asymmetric synapses in layer 4 of area 17 of cats formed by ... Read more...
Latest indexed articles for 'Synapses - Ultrastructure'
These are the very latest articles for this heading:
- ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. 27 Oct 2009
- Input-specific intrasynaptic arrangements of ionotropic glutamate receptors and their impact on postsynaptic responses. 12 Oct 2009
- The proportion of synapses formed by the axons of the lateral geniculate nucleus in layer 4 of area 17 of the cat. 29 Sep 2009
- Ultrastructural analysis of local collaterals of rat ventral tegmental area neurons: GABA phenotype and synapses onto dopamine and GABA cells. 29 Sep 2009
- High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling. 22 Sep 2009
- NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity. 21 Sep 2009
- The synaptic connections between cortical areas V1 and V2 in macaque monkey. 7 Sep 2009
- The W cell pathway to cat primary visual cortex. 30 Aug 2009
- Otoferlin is critical for a highly sensitive and linear calcium-dependent exocytosis at vestibular hair cell ribbon synapses. 24 Aug 2009
- Synaptic organization of the tectorecipient zone of the rat lateral posterior nucleus. 18 Aug 2009
- N-methyl-D-aspartate receptor independent changes in expression of polysialic acid-neural cell adhesion molecule despite blockade of homosynaptic long-term potentiation and heterosynaptic long-term depression in the awake freely behaving rat dentate gyrus. 11 Aug 2009
- Abi plays an opposing role to Abl in Drosophila axonogenesis and synaptogenesis. 10 Aug 2009
- Glycinergic projection neurons of the cerebellum. 10 Aug 2009
- Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury. 31 Jul 2009
- Eyeblink conditioning leads to fewer synapses in the rabbit cerebellar cortex. 30 Jul 2009
- Ultrastructure of the retinal synapses in cubozoans. 30 Jul 2009
- Synaptic potentiation induces increased glial coverage of excitatory synapses in CA1 hippocampus. 30 Jul 2009
- Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus. 30 Jul 2009
- Perisomatic-targeting granule cells in the mouse olfactory bulb. 30 Jul 2009
- Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. 28 Jul 2009
See a longer list of these articles.
Technical information about 'Synapses'
Definition: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.
Descriptor UI: D013569
Alternative terms: Synapses; Synapse;
Related Mesh Headings: Synaptic Transmission; Synaptosomes; Gap Junctions;
Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; ultrastructure; ultrasonography; chemistry; virology; genetics;
Tree Number: A08.850; A11.284.149.165.420.780;
Technical Notes: note specifics; IMMUNOLOGICAL SYNAPSES is also available; / physiol: consider also SYNAPTIC TRANSMISSION; do not confuse with SYNAPSIS see CHROMOSOME PAIRING