Synaptophysin
Research News and Information

Sunday, November 22, 2009

From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior.

30 Oct 2009 The prognosis in children harboring a glioblastoma multiforme (GBM) is usually poor. Few GBMs in children, however, seem to respond quite well to adjuvant chemotherapy. The biological basis for such chemotherapy sensitivity remains uncertain. In ... Read more...

Abnormality of synaptic vesicular associated proteins in cerebral cortex and hippocampus after microwave exposure.

30 Oct 2009 Studies were performed to determine the effects of microwave on synaptic vesicles and the expression of synaptic vesicular associated proteins including synapsin I, VAMP-2, syntaxin, and synaptophysin. 25 Wistar rats were exposed to microwave which ... Read more...

Microtubule-associated protein-2 is a sensitive marker of primary and metastatic neuroblastoma.

30 Oct 2009 BACKGROUND: Microtubule-associated protein-2 (MAP-2) is a protein expressed in high levels in cells derived from the neural crest. To the best of our knowledge, MAP-2 expression has not been thoroughly evaluated in tissues outside of the central ... Read more...

Latest indexed articles for 'Synaptophysin'

These are the very latest articles for this heading:

• From glioblastoma to gangliocytoma: an unforeseen but welcome shift in biological behavior. 30 Oct 2009
• Abnormality of synaptic vesicular associated proteins in cerebral cortex and hippocampus after microwave exposure. 30 Oct 2009
• Microtubule-associated protein-2 is a sensitive marker of primary and metastatic neuroblastoma. 30 Oct 2009
• Aberrant expression of class III beta-tubulin in basal cell carcinoma of the skin. 29 Sep 2009
• Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src. 6 Sep 2009
• Changes in markers of neuronal and glial plasticity after cortical injury induced by food restriction. 2 Sep 2009
• [Small cell carcinoma of extrahepatic bile duct presenting with hemobilia] 30 Aug 2009
• Medullary thyroid carcinoma with poor differentiation and atypical radiographic pattern of metastasis. 30 Aug 2009
• Flow cytometric detection of small cell lung cancer cells with aberrant CD45 expression in micrometastatic bone marrow. 10 Aug 2009
• Oxygen treatment triggers cognitive impairment in Alzheimer's transgenic mice. 3 Aug 2009
• Clinical relevance of neuroendocrine differentiation in non-small cell lung cancer assessed by immunohistochemistry: a retrospective study on 405 surgically resected cases. 2 Aug 2009
• Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus. 30 Jul 2009
• Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood. 30 Jul 2009
• Histone modifier, the gatekeeper of good memory. 30 Jul 2009
• Asymptomatic children with multiple endocrine neoplasia type 1 mutations may harbor nonfunctioning pancreatic neuroendocrine tumors. 19 Jul 2009
• Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration. 18 Jul 2009
• Glioblastoma with primitive neuroectodermal tumor-like features: case report. 29 Jun 2009
• Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. 29 Jun 2009
• The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cells. 29 Jun 2009
• Myenteric plexus alterations downstream from a prenatal intestinal obstruction in a rat model. 15 Jun 2009

See a longer list of these articles.

Technical information about 'Synaptophysin'

Definition: A 38-kDa integral membrane glycoprotein of the presynaptic vesicles in neuron and neuroendocrine cells. It is expressed by a variety of normal and neoplastic neuroendocrine cells and is therefore used as an immunocytochemical marker for neuroendocrine differentiation in various tumors. In ALZHEIMER DISEASE and other dementing disorders, there is an important synapse loss due in part to a decrease of synaptophysin in the presynaptic vesicles.

Registry Number: 0

Descriptor UI: D016708

Alternative terms: Synaptophysin; P38 Membrane Protein, Synaptic Vesicle; Protein P38, Synaptic Vesicle; Synaptophysin, Rat Clone pSR(2) Protein Moiety, Reduced;

Allowable Qualifiers: administration & dosage; adverse effects; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; drug effects; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; ultrastructure; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.395.550.800; D12.776.543.550.800; D12.776.641.800; D23.101.840.800;

Online Note: use SYNAPTOPHYSIN (NM) to search SYNAPTOPHYSIN 1985-91

History Note: 92; was SYNAPTOPHYSIN (NM) 1985-91

Technical Notes: /biosyn /drug eff /physiol /ultrastruct permitted