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Synaptosomes - Metabolism
Research News and Information
Definition of 'Synaptosomes'Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates. Common names: Synaptosomes; Synaptosome |
Sunday, November 22, 2009
ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.
27 Oct 2009 
The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, ... Read more...
30 Aug 2009 In this study, we have examined the role of corticosterone (CORT) in the regulation of neuronal glutamate release using nerve terminals (synaptosomes) isolated from the rat hippocampus. Adult male Sprague-Dawley rats received either a chronic ... Read more...
13 Aug 2009 D-serine is an endogenous coagonist of N-methyl-D-aspartate (NMDA) receptors that plays an important role in synaptic function, neuronal development, and excitotoxicity. Mechanisms of D-serine transport are important in regulation of extracellular ... Read more...
Latest indexed articles for 'Synaptosomes - Metabolism'
These are the very latest articles for this heading:
- ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. 27 Oct 2009
- Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals. 30 Aug 2009
- Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures. 13 Aug 2009
- Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. 13 Aug 2009
- Oral administration of coenzyme Q(10) prevents cytochrome c release from mitochondria induced by 1-methyl-4-phenylpyridinium ion in mouse brain synaptosomes. 24 Jul 2009
- Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease. 23 Jul 2009
- Role of copper and manganese in prion disease progression. 23 Jul 2009
- Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. 21 Jul 2009
- Synaptic mRNAs are modulated by learning. 29 Jun 2009
- ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. 29 Jun 2009
- Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. 23 Jun 2009
- Glutamate transporter coupling to Na,K-ATPase. 22 Jun 2009
- Long-term potentiation in isolated dendritic spines.
21 Jun 2009 - Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. 20 Jun 2009
- L-aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes. 20 Jun 2009
- Selectivity of ABT-089 for alpha4beta2* and alpha6beta2* nicotinic acetylcholine receptors in brain. 25 May 2009
- Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. 18 May 2009
- In vitro assessment of paraoxon effects on GABA uptake in rat hippocampal synaptosomes. 17 May 2009
- Transport of AMPA receptors during long-term potentiation is impaired in rats with hepatic encephalopathy. 16 May 2009
- IL-6 mediated degeneration of forebrain GABAergic interneurons and cognitive impairment in aged mice through activation of neuronal NADPH oxidase. 11 May 2009
See a longer list of these articles.
Technical information about 'Synaptosomes'
Definition: Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.
Descriptor UI: D013574
Alternative terms: Synaptosomes; Synaptosome;
Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;
Tree Number: A11.284.835.859;
History Note: 74(72)
Technical Notes: A 11 qualif except /cytol