Synaptosomes - Ultrastructure
Research News and Information

Sunday, November 22, 2009

ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.

27 Oct 2009 The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, ... Read more...

Synaptic mRNAs are modulated by learning.

29 Jun 2009 We have recently demonstrated that brain plastic events significantly modify synaptic protein synthesis measured by the incorporation of [(35)S]methionine in brain synaptosomal proteins. Notably, in rats learning a two-way active avoidance task, the ... Read more...

Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells.

20 Jun 2009 Activation of G protein-gated inwardly-rectifying K(+) (GIRK or Kir3) channels by metabotropic gamma-aminobutyric acid (B) (GABA(B)) receptors is an essential signalling pathway controlling neuronal excitability and synaptic transmission in the ... Read more...

Latest indexed articles for 'Synaptosomes - Ultrastructure'

These are the very latest articles for this heading:

• ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. 27 Oct 2009
• Synaptic mRNAs are modulated by learning. 29 Jun 2009
• Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. 20 Jun 2009
• Secreted amyloid precursor protein-alpha upregulates synaptic protein synthesis by a protein kinase G-dependent mechanism. 18 May 2009
• Porosome: the secretory portal in cells. 17 May 2009
• Nicotine-induced and depolarisation-induced glutamate release from hippocampus mossy fibre synaptosomes: two distinct mechanisms. 13 May 2009
• The post-synaptic density of human postmortem brain tissues: an experimental study paradigm for neuropsychiatric illnesses. 14 Apr 2009
• Transcriptome analysis of synaptoneurosomes identifies neuroplasticity genes overexpressed in incipient Alzheimer's disease. 17 Mar 2009
• The natural xanthone alpha-mangostin reduces oxidative damage in rat brain tissue. 30 Jan 2009
• Altered Ca2+ dependence of synaptosomal plasma membrane Ca2+-ATPase in human brain affected by Alzheimer's disease. 12 Jan 2009
• Porosome: the universal molecular machinery for cell secretion. 29 Dec 2008
• Pre-synaptic GABA receptors inhibit glutamate release through GIRK channels in rat cerebral cortex. 29 Nov 2008
• Isoflurane-induced depolarization of neural mitochondria increases with age. 10 Nov 2008
• Membrane lipids and morphology of brain cortex synaptosomes isolated from hibernating Yakutian ground squirrel. 7 Aug 2008
• Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid beta-protein fibrillogenesis. 5 Aug 2008
• Critical role of TRPC6 channels in the formation of excitatory synapses. 28 May 2008
• Pre-synaptic and post-synaptic localization of EphA4 and EphB2 in adult mouse forebrain. 10 Apr 2008
• Cytoplasmic calcium mediates oxidative damage in an excitotoxic /energetic deficit synergic model in rats. 28 Feb 2008
• The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. 31 Dec 2007
• Intracellular organelle dynamics at nm resolution. 30 Dec 2007

See a longer list of these articles.

Technical information about 'Synaptosomes'

Definition: Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.

Descriptor UI: D013574

Alternative terms: Synaptosomes; Synaptosome;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A11.284.835.859;

History Note: 74(72)

Technical Notes: A 11 qualif except /cytol