Synaptosomes
Research News and Information

Monday, November 23, 2009

ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses.

27 Oct 2009 The presynaptic active zone is composed of a protein network that contains ELKS2alpha (a.k.a. CAST) as a central component. Here we demonstrate that in mice, deletion of ELKS2alpha caused a large increase in inhibitory, but not excitatory, ... Read more...

Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src.

6 Sep 2009 Peroxynitrite is a potent oxidant that contributes to tissue damage in neurodegenerative disorders. We have previously reported that treatment of rat brain synaptosomes with peroxynitrite induced post-translational modifications in pre- and ... Read more...

Facilitation of glutamate release from rat cerebral cortex nerve terminal by subanesthetic concentration propofol.

30 Aug 2009 Propofol is now the most commonly used intravenous anesthetic-for general anesthesia and sedation because of its rapid onset and recovery. Besides the well-known adverse effects of cardiovascular and respiratory depression, recent studies indicate ... Read more...

Latest indexed articles for 'Synaptosomes'

These are the very latest articles for this heading:

• ELKS2alpha/CAST deletion selectively increases neurotransmitter release at inhibitory synapses. 27 Oct 2009
• Peroxynitrite induces tyrosine residue modifications in synaptophysin C-terminal domain, affecting its interaction with src. 6 Sep 2009
• Facilitation of glutamate release from rat cerebral cortex nerve terminal by subanesthetic concentration propofol. 30 Aug 2009
• Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals. 30 Aug 2009
• Hydrogen sulfide is a reversible inhibitor of the NADH oxidase activity of synaptic plasma membranes. 16 Aug 2009
• Functional and immunocytochemical characterization of D-serine transporters in cortical neuron and astrocyte cultures. 13 Aug 2009
• Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes. 13 Aug 2009
• Oral administration of coenzyme Q(10) prevents cytochrome c release from mitochondria induced by 1-methyl-4-phenylpyridinium ion in mouse brain synaptosomes. 24 Jul 2009
• Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease. 23 Jul 2009
• Role of copper and manganese in prion disease progression. 23 Jul 2009
• Cyclin-dependent kinase 5 inhibitors: inhibition of dopamine transporter activity. 21 Jul 2009
• Pyridoxine inhibits depolarization-evoked glutamate release in nerve terminals from rat cerebral cortex: a possible neuroprotective mechanism? 21 Jul 2009
• Synaptic mRNAs are modulated by learning. 29 Jun 2009
• ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. 29 Jun 2009
• Early nerve ending rescue from oxidative damage and energy failure by L: -carnitine as post-treatment in two neurotoxic models in rat: recovery of antioxidant and reductive capacities. 28 Jun 2009
• Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. 23 Jun 2009
• Glutamate transporter coupling to Na,K-ATPase. 22 Jun 2009
• Long-term potentiation in isolated dendritic spines. 21 Jun 2009
• Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. 20 Jun 2009
• L-aspartate as an amino acid neurotransmitter: mechanisms of the depolarization-induced release from cerebrocortical synaptosomes. 20 Jun 2009

See a longer list of these articles.

Technical information about 'Synaptosomes'

Definition: Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.

Descriptor UI: D013574

Alternative terms: Synaptosomes; Synaptosome;

Allowable Qualifiers: classification; drug effects; enzymology; immunology; metabolism; microbiology; parasitology; pathology; physiology; radiation effects; radiography; radionuclide imaging; secretion; transplantation; ultrastructure; ultrasonography; chemistry; virology;

Tree Number: A11.284.835.859;

History Note: 74(72)

Technical Notes: A 11 qualif except /cytol