Syndecan-2
Research News and Information

Tuesday, November 24, 2009

Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo.

30 Aug 2009 One of the first steps in zebrafish heart and gut organogenesis is the migration of bilateral primordia to the midline to form cardiac and gut tubes. The mechanisms that regulate this process are poorly understood. Here we show that the proteoglycan ... Read more...

Is syndecan-2 a key angiogenic element?

30 Jul 2009 Angiogenesis has been extensively related with the development of many different diseases, from tumor progression to cardiovascular disorders. In our last article, we demonstrated that syndecan-2, the most abundant heparan sulfate proteoglycan ... Read more...

Syndecan-2 regulates the migratory potential of melanoma cells.

27 Jul 2009 Syndecan-2, a transmembrane heparan sulfate proteoglycan, is a critical mediator in the tumorigenesis of colon carcinoma cells. We explored the function of syndecan-2 in melanoma, one of the most invasive types of cancers, and found that the ... Read more...

Latest indexed articles for 'Syndecan-2'

These are the very latest articles for this heading:

• Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo. 30 Aug 2009
• Is syndecan-2 a key angiogenic element? 30 Jul 2009
• Syndecan-2 regulates the migratory potential of melanoma cells. 27 Jul 2009
• The RNA-binding protein Mex3b has a fine-tuning system for mRNA regulation in early Xenopus development. 29 Jun 2009
• Expression of pleiotrophin and its receptors in human placenta suggests roles in trophoblast life cycle and angiogenesis. 26 May 2009
• Syndecan-2 overexpression regulates adhesion and migration through cooperation with integrin alpha2. 22 Apr 2009
• Prognostic significance of altered expression of SDC2 and CYR61 in esophageal squamous cell carcinoma. 30 Mar 2009
• Expression of syndecan-2 in the amoeboid microglial cells and its involvement in inflammation in the hypoxic developing brain. 30 Jan 2009
• Solution structure of synbindin atypical PDZ domain and interaction with syndecan-2. 30 Dec 2008
• Syndecan-2 downregulation impairs angiogenesis in human microvascular endothelial cells. Dec 2008
• The survival-promoting peptide Y-P30 enhances binding of pleiotrophin to syndecan-2 and -3 and supports its neuritogenic activity. Jul 2008
• Estradiol-estrogen receptor: a key interplay of the expression of syndecan-2 and metalloproteinase-9 in breast cancer cells. 16 Jun 2008
• Syndecan-2 and -4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation. 12 Mar 2008
• Opposing roles of syndecan-1 and syndecan-2 in polyethyleneimine-mediated gene delivery. 21 Jan 2008
• Cryptic fragment alpha4 LG4-5 derived from laminin alpha4 chain inhibits de novo adipogenesis by modulating the effect of fibroblast growth factor-2. 5 Dec 2007
• Requirements for sulfate transport and the diastrophic dysplasia sulfate transporter in fibronectin matrix assembly. Dec 2007
• Expression of cell-surface heparan sulfate proteoglycans in human cyclosporin-induced gingival overgrowth. 29 Nov 2007
• Increased levels of xylosyltransferase I correlate with the mineralization of the extracellular matrix during osteogenic differentiation of mesenchymal stem cells. 7 Oct 2007
• Syndecans are differentially expressed during the course of aortic aneurysm formation. 29 Sep 2007
• Syndecans promote integrin-mediated adhesion of mesenchymal cells in two distinct pathways. 8 Aug 2007

See a longer list of these articles.

Technical information about 'Syndecan-2'

Definition: A syndecan that is predominantly expressed during EMBRYONIC DEVELOPMENT. It may play a role in mediating cellular interactions with the EXTRACELLULAR MATRIX and may modulate the signaling activity of certain INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS.

Registry Number: 149769-25-5

Descriptor UI: D053669

Alternative terms: Syndecan-2; Syndecan 2; Fibroglycan; Heparan Sulfate Proteoglycan Core Protein;

Allowable Qualifiers: administration & dosage; adverse effects; analogs & derivatives; analysis; antagonists & inhibitors; biosynthesis; blood; cerebrospinal fluid; chemical synthesis; classification; deficiency; diagnostic use; economics; genetics; history; immunology; isolation & purification; metabolism; pharmacokinetics; pharmacology; physiology; poisoning; radiation effects; secretion; standards; supply & distribution; therapeutic use; toxicity; urine; chemistry; contraindications; agonists;

Tree Number: D12.776.395.550.847.200; D12.776.395.650.350.500.200; D12.776.543.550.847.200;

History Note: 2007(1992)