Systems Biology - Methods
Research News and Information

Monday, November 23, 2009

Disease signatures are robust across tissues and experiments.

13 Sep 2009 Meta-analyses combining gene expression microarray experiments offer new insights into the molecular pathophysiology of disease not evident from individual experiments. Although the established technical reproducibility of microarrays serves as a ... Read more...

Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism.

13 Sep 2009 Central carbon metabolism is a basic and exhaustively analyzed pathway. However, the intrinsic robustness of the pathway might still conceal uncharacterized reactions. To test this hypothesis, we constructed systematic multiple-knockout mutants ... Read more...

Evidence for a major role of antisense RNAs in cyanobacterial gene regulation.

13 Sep 2009 Information on the numbers and functions of naturally occurring antisense RNAs (asRNAs) in eubacteria has thus far remained incomplete. Here, we screened the model cyanobacterium Synechocystis sp. PCC 6803 for asRNAs using four different methods. In ... Read more...

Latest indexed articles for 'Systems Biology - Methods'

These are the very latest articles for this heading:

• Disease signatures are robust across tissues and experiments. 13 Sep 2009
• Systematic phenome analysis of Escherichia coli multiple-knockout mutants reveals hidden reactions in central carbon metabolism. 13 Sep 2009
• Evidence for a major role of antisense RNAs in cyanobacterial gene regulation. 13 Sep 2009
• A simple and efficient algorithm for genome-wide homozygosity analysis in disease. 13 Sep 2009
• The systems biology-based argument for taking a bold step in chemoprophylaxis of sickle vasculopathy. 30 Aug 2009
• Working towards an exegesis for lipids in biology. 30 Aug 2009
• Applying mass spectrometry-based proteomics to genetics, genomics and network biology. 30 Aug 2009
• Strong inference for systems biology. 26 Aug 2009
• From SNPs to pathways: integration of functional effect of sequence variations on models of cell signalling pathways. 25 Aug 2009
• Metabolomics-driven quantitative analysis of ammonia assimilation in E. coli. 16 Aug 2009
• A mechanical bottleneck explains the variation in cup growth during FcgammaR phagocytosis. 16 Aug 2009
• Quantifying epistatic interactions among the components constituting the protein translation system. 16 Aug 2009
• Large-scale identification of genetic design strategies using local search. 16 Aug 2009
• Immunopurification of Ago1 miRNPs selects for a distinct class of microRNA targets. 16 Aug 2009
• Return of the rat. 11 Aug 2009
• Computational approaches to the integration of gene expression, ChIP-chip and sequence data in the inference of gene regulatory networks. 10 Aug 2009
• A systems biology approach to understanding cis-regulatory module function. 2 Aug 2009
• Generating rate equations for complex enzyme systems by a computer-assisted systematic method. 2 Aug 2009
• Who will take up the gauntlet? Challenges and opportunities for systems biology and drug discovery. 30 Jul 2009
• A new revolution? The place of systems biology and synthetic biology in the history of biology. 30 Jul 2009

See a longer list of these articles.

Technical information about 'Systems Biology'

Definition: Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.

Descriptor UI: D049490

Alternative terms: Systems Biology; Biology, Systems;

Related Mesh Headings: Systems Theory;

Allowable Qualifiers: classification; economics; education; history; instrumentation; legislation & jurisprudence; manpower; methods; organization & administration; standards; trends; statistics & numerical data; ethics;

Tree Number: H01.158.273.180.800;

History Note: 2005