T-Cell Antigen Receptor Specificity
Research News and Information

Monday, November 23, 2009

Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells.

12 Aug 2009 Although recent studies have focused on CD4(+) regulatory T cells (Treg), CD8(+) Treg have also been reported to play important roles in the induction and maintenance of immune tolerance. Adoptive transfer of CD8(+) Treg in rodents or induction of ... Read more...

In vitro tests in drug hypersensitivity diagnosis.

30 Jul 2009 The diagnosis of a drug hypersensitivity reaction (DHR) is a challenging task because multiple and complex mechanisms are involved. Better understanding of immunologic pathomechanisms in DHRs and rapid progress in cellular-based in-vitro tests can ... Read more...

Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells.

18 Jul 2009 The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5-HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4(+) T ... Read more...

Latest indexed articles for 'T-Cell Antigen Receptor Specificity'

These are the very latest articles for this heading:

• Efficient induction and expansion of human alloantigen-specific CD8 regulatory T cells from naive precursors by CD40-activated B cells. 12 Aug 2009
• In vitro tests in drug hypersensitivity diagnosis. 30 Jul 2009
• Baseline Ad5 serostatus does not predict Ad5 HIV vaccine-induced expansion of adenovirus-specific CD4+ T cells. 18 Jul 2009
• Adenovirus-specific immunity after immunization with an Ad5 HIV-1 vaccine candidate in humans. 18 Jul 2009
• Processing of two latent membrane protein 1 MHC class I epitopes requires tripeptidyl peptidase II involvement. 6 Jul 2009
• Insufficient TLR activation contributes to the slow development of CD8+ T cell responses in Trypanosoma cruzi infection. 22 Jun 2009
• Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response. 17 Jun 2009
• Vaccination with recombinant NY-ESO-1 protein elicits immunodominant HLA-DR52b-restricted CD4+ T cell responses with a conserved T cell receptor repertoire. 14 Jun 2009
• Murine Th clones confer late asthmatic response upon antigen challenge. Jun 2009
• Detailed analysis of IFNg response upon activation permits efficient isolation of cytomegalovirus-specific CD8+ T cells for adoptive immunotherapy. 30 May 2009
• Kinetics of expansion of epitope-specific T cell responses during primary HIV-1 infection. 30 May 2009
• Cutting edge: Highly alloreactive dual TCR T cells play a dominant role in graft-versus-host disease. 30 May 2009
• Donor-specific reactivity and Th1 cytokines--implications for immunologic monitoring. 25 May 2009
• Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. 16 May 2009
• Intracellular bacterial vectors that induce CD8(+) T cells with similar cytolytic abilities but disparate memory phenotypes provide contrasting tumor protection. 10 May 2009
• NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses. 28 Apr 2009
• A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS. 21 Apr 2009
• IL-15 protects antigen-specific CD8+ T cell contraction after Mycobacterium bovis bacillus Calmette-Guérin infection. 21 Apr 2009
• IL-7 adjuvant treatment enhances long-term tumor-antigen-specific CD8+ T-cell responses after immunization with recombinant lentivector. 19 Apr 2009
• Analysis of positive kidney, heart, and liver transplant crossmatches reported to the Collaborative Transplant Study. 13 Apr 2009

See a longer list of these articles.

Technical information about 'T-Cell Antigen Receptor Specificity'

Definition: The property of the T-CELL RECEPTOR which enables it to react with some antigens and not others. The specificity is derived from the structure of the receptor's variable region which has the ability to recognize certain antigens in conjunction with the MAJOR HISTOCOMPATIBILITY COMPLEX molecule.

Descriptor UI: D037182

Alternative terms: T-Cell Antigen Receptor Specificity; T Cell Antigen Receptor Specificity; T-Cell Receptor Specificity; Specificity, T-Cell Receptor; T Cell Receptor Specificity; T-Cell Specificity; Specificity, T-Cell; T Cell Specificity; T-Cell Immunologic Specificity; Immunologic Specificity, T-Cell; Specificity, T-Cell Immunologic; T Cell Immunologic Specificity;

Related Mesh Headings: Antibody Specificity;

Allowable Qualifiers: drug effects; genetics; immunology; physiology; radiation effects;

Tree Number: G12.450.900;

History Note: 2003

Technical Notes: T-cell cross-reactivity goes here