 |
Tandem Mass Spectrometry - Methods
Research News and Information
Definition of 'Tandem Mass Spectrometry'A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection. |
Sunday, November 22, 2009
12 Oct 2009 
Amyloid beta protein (Abeta), a pathogenic molecule associated with Alzheimer's disease, is produced by gamma-secretase, which cleaves the beta-carboxyl terminal fragment (betaCTF) of beta-amyloid precursor protein in the middle of its transmembrane ... Read more...
29 Sep 2009 BACKGROUND: The European DRUID (Driving under the Influence of Drugs, Alcohol And Medicines) project calls for analysis of oral fluid (OF) samples, collected randomly and anonymously at the roadside from drivers in Denmark throughout 2008-2009. To ... Read more...
Comparative bioavailability of two formulations of sibutramine.
29 Sep 2009 This study was conducted in order to compare the bioavailability of two capsule formulations containing 15 mg of sibutramine, N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine hydrochloride monohydrate, 84485-00-7 CAS registry ... Read more...
Latest indexed articles for 'Tandem Mass Spectrometry - Methods'
These are the very latest articles for this heading:
- gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. 12 Oct 2009
- Simultaneous screening and quantification of 29 drugs of abuse in oral fluid by solid-phase extraction and ultraperformance LC-MS/MS. 29 Sep 2009
- Comparative bioavailability of two formulations of sibutramine. 29 Sep 2009
- Investigation of uremic analytes in hemodialysate and their structural elucidation from accurate mass maps generated by a multi-dimensional liquid chromatography/mass spectrometry approach. 29 Sep 2009
- High-throughput ultra-high-performance liquid chromatography/tandem mass spectrometry quantitation of insulin-like growth factor-I and leucine-rich alpha-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration. 29 Sep 2009
- Structural determination of sildenafil and its analogues in dietary supplements by fast-atom bombardment collision-induced dissociation tandem mass spectrometry. 29 Sep 2009
- Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry. 29 Sep 2009
- Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry. 29 Sep 2009
- Sterically hindered phenols in negative ion mobility spectrometry-mass spectrometry. 29 Sep 2009
- Comparison of urinary albumin quantification by immunoturbidimetry, competitive immunoassay, and protein-cleavage liquid chromatography-tandem mass spectrometry. 8 Sep 2009
- Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. 6 Sep 2009
- Isotope dilution method for determination of polybrominated diphenyl ethers using liquid chromatography coupled to negative ionization atmospheric pressure photoionization tandem mass spectrometry: validation and application to house dust. 30 Aug 2009
- Nonprotein based enrichment method to analyze peptide cross-linking in protein complexes. 30 Aug 2009
- Evaluation of several MS/MS search algorithms for analysis of spectra derived from electron transfer dissociation experiments. 30 Aug 2009
- Electron-capture dissociation (ECD), collision-induced dissociation (CID) and ECD/CID in a linear radio-frequency-free magnetic cell.
30 Aug 2009 - Two-injection workflow for a liquid chromatography/LTQ-Orbitrap system to complete in vivo biotransformation characterization: demonstration with buspirone metabolite identification. 30 Aug 2009
- Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry. 30 Aug 2009
- Targeted analysis of protein citrullination using chemical modification and tandem mass spectrometry. 30 Aug 2009
- Electrospray ionization tandem mass spectrometric characteristics of d4T H-phosphonate and distamycin conjugates. 30 Aug 2009
- Infrared spectrum of potassium-cationized triethylphosphate generated using tandem mass spectrometry and infrared multiple photon dissociation. 30 Aug 2009
See a longer list of these articles.
Technical information about 'Tandem Mass Spectrometry'
Definition: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Descriptor UI: D053719
Alternative terms: Tandem Mass Spectrometry; Mass Spectrometry, Tandem; Mass Spectrometry-Mass Spectrometry; Mass Spectrometry Mass Spectrometry;
Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;
Tree Number: E05.196.566.880;
History Note: 2007