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Tandem Mass Spectrometry
Research News and Information
Definition of 'Tandem Mass Spectrometry'A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection. |
Monday, November 23, 2009
8 Nov 2009 
Pili are surface-linked virulence factors that play key roles in infection establishment in a variety of pathogenic species. In Gram-positive pathogens, pilus formation requires the action of sortases, dedicated transpeptidases that covalently ... Read more...
12 Oct 2009 Amyloid beta protein (Abeta), a pathogenic molecule associated with Alzheimer's disease, is produced by gamma-secretase, which cleaves the beta-carboxyl terminal fragment (betaCTF) of beta-amyloid precursor protein in the middle of its transmembrane ... Read more...
Proteomic and genetic approaches identify Syk as an AML target.
4 Oct 2009 Cell-based screening can facilitate the rapid identification of compounds inducing complex cellular phenotypes. Advancing a compound toward the clinic, however, generally requires the identification of precise mechanisms of action. We previously ... Read more...
Latest indexed articles for 'Tandem Mass Spectrometry'
These are the very latest articles for this heading:
- Sortase activity is controlled by a flexible lid in the pilus biogenesis mechanism of gram-positive pathogens. 8 Nov 2009
- gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment. 12 Oct 2009
- Proteomic and genetic approaches identify Syk as an AML target. 4 Oct 2009
- Simultaneous screening and quantification of 29 drugs of abuse in oral fluid by solid-phase extraction and ultraperformance LC-MS/MS. 29 Sep 2009
- Comparative bioavailability of two formulations of sibutramine. 29 Sep 2009
- Investigation of uremic analytes in hemodialysate and their structural elucidation from accurate mass maps generated by a multi-dimensional liquid chromatography/mass spectrometry approach. 29 Sep 2009
- High-throughput ultra-high-performance liquid chromatography/tandem mass spectrometry quantitation of insulin-like growth factor-I and leucine-rich alpha-2-glycoprotein in serum as biomarkers of recombinant human growth hormone administration. 29 Sep 2009
- Structural determination of sildenafil and its analogues in dietary supplements by fast-atom bombardment collision-induced dissociation tandem mass spectrometry. 29 Sep 2009
- Simultaneous quantification of 2',2'-difluorodeoxycytidine and 2',2'-difluorodeoxyuridine nucleosides and nucleotides in white blood cells using porous graphitic carbon chromatography coupled with tandem mass spectrometry. 29 Sep 2009
- Multi-residue analysis of eight thioamphetamine designer drugs in human urine by liquid chromatography/tandem mass spectrometry. 29 Sep 2009
- Sterically hindered phenols in negative ion mobility spectrometry-mass spectrometry. 29 Sep 2009
- Metabolomics for biotransformations: Intracellular redox cofactor analysis and enzyme kinetics offer insight into whole cell processes. 29 Sep 2009
- Distinct changes in soybean xylem sap proteome in response to pathogenic and symbiotic microbe interactions. 19 Sep 2009
- Identification of the amniotic fluid insulin-like growth factor binding protein-1 phosphorylation sites and propensity to proteolysis of the isoforms. 15 Sep 2009
- Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry. 13 Sep 2009
- Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2. 13 Sep 2009
- Motility and flagellar glycosylation in Clostridium difficile. 9 Sep 2009
- Comparison of urinary albumin quantification by immunoturbidimetry, competitive immunoassay, and protein-cleavage liquid chromatography-tandem mass spectrometry. 8 Sep 2009
- Clear differences in levels of a formaldehyde-DNA adduct in leukocytes of smokers and nonsmokers. 6 Sep 2009
- Transcriptome and proteome analyses of adaptive responses to methyl methanesulfonate in Escherichia coli K-12 and ada mutant strains. Sep 2009
See a longer list of these articles.
Technical information about 'Tandem Mass Spectrometry'
Definition: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
Descriptor UI: D053719
Alternative terms: Tandem Mass Spectrometry; Mass Spectrometry, Tandem; Mass Spectrometry-Mass Spectrometry; Mass Spectrometry Mass Spectrometry;
Allowable Qualifiers: classification; economics; history; instrumentation; methods; standards; trends; utilization; veterinary; statistics & numerical data; ethics;
Tree Number: E05.196.566.880;
History Note: 2007